Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571973263> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1571973263 abstract "Myocardial lactate production (MLP) in the coronary circulation is a supporting diagnostic marker useful in the evaluation of coronary spasm-induced myocardial ischemia during acetylcholine (ACh)-provocation test. We previously found a -786T/C polymorphism in the 5’-flanking region of the endothelial nitric oxide synthase (eNOS) gene and reported that this polymorphism is strongly associated with coronary spasm. However, there is no report showing the relation between MLP induced by ACh-provocation test and eNOS gene -786T/C polymorphism in the large study population. We examined 712 consecutive patients who underwent myocardial lactate measurement during ACh-provocation test and agreed with genetic screening test of eNOS gene -786T/C polymorphism between January 1991 and December 2010. ACh-provoked MLP was observed in 252 out of 712 patients included in the present analysis [252 MLP-positive and 460 MLP-negative patients]. MLP-positive patients were more likely to be female, diabetic, non-smokers, had epicardial, multivessel and diffuse spasm pattern, with eNOS-786T/C polymorphism (60% vs. 44%, p<0.001, 25% vs. 19%, p=0.047, 61% vs. 46%, p<0.001, 83% vs. 36%, p<0.001, 37% vs. 11%, p<0.001, 39% vs. 12%, p<0.001, and 23% vs. 15%, p=0.011, respectively). Multiple logistic regression analysis identified female gender, epicardial spasm and -786T/C polymorphism to correlate with the MLP-positive finding (OR: 0.327; 95% CI: 0.226-0.475; p<0.001, OR: 10.137; 95% CI: 6.767-15.187; p<0.001, and OR: 1.621; 95% CI: 1.025-2.564; p= 0.039). In the analysis of patients with epicardial coronary spasm, Kaplan-Meier survival curve showed no difference in 5-year survival rates free from major adverse cardiac events between MLP-positive and MLP-negative patients with epicardial coronary spasm (p=NS). In conclusion, multiple predictors including female gender and eNOS gene -786T/C polymorphism were the significant predictors for the MLP induced by ACh-provocation test, highlighting the close relation between the genetic factors and ACh-induced myocardial ischemia in Japanese patients with coronary vasospastic angina." @default.
- W1571973263 created "2016-06-24" @default.
- W1571973263 creator A5020090012 @default.
- W1571973263 creator A5020527263 @default.
- W1571973263 creator A5029987938 @default.
- W1571973263 creator A5049895325 @default.
- W1571973263 creator A5072680574 @default.
- W1571973263 creator A5073078229 @default.
- W1571973263 creator A5079485654 @default.
- W1571973263 date "2014-11-25" @default.
- W1571973263 modified "2023-09-23" @default.
- W1571973263 title "Abstract 11228: The Endothelial Nitric Oxide Synthase Gene -786T/C Polymorphism is a Significant Predictive Factor for Myocardial Lactate Production During Acetylcholine-Provoked Coronary Spasm" @default.
- W1571973263 hasPublicationYear "2014" @default.
- W1571973263 type Work @default.
- W1571973263 sameAs 1571973263 @default.
- W1571973263 citedByCount "0" @default.
- W1571973263 crossrefType "journal-article" @default.
- W1571973263 hasAuthorship W1571973263A5020090012 @default.
- W1571973263 hasAuthorship W1571973263A5020527263 @default.
- W1571973263 hasAuthorship W1571973263A5029987938 @default.
- W1571973263 hasAuthorship W1571973263A5049895325 @default.
- W1571973263 hasAuthorship W1571973263A5072680574 @default.
- W1571973263 hasAuthorship W1571973263A5073078229 @default.
- W1571973263 hasAuthorship W1571973263A5079485654 @default.
- W1571973263 hasConcept C110586980 @default.
- W1571973263 hasConcept C126322002 @default.
- W1571973263 hasConcept C134018914 @default.
- W1571973263 hasConcept C142724271 @default.
- W1571973263 hasConcept C164705383 @default.
- W1571973263 hasConcept C204787440 @default.
- W1571973263 hasConcept C2777622882 @default.
- W1571973263 hasConcept C2778326061 @default.
- W1571973263 hasConcept C2908647359 @default.
- W1571973263 hasConcept C42219234 @default.
- W1571973263 hasConcept C519581460 @default.
- W1571973263 hasConcept C71924100 @default.
- W1571973263 hasConcept C90924648 @default.
- W1571973263 hasConcept C99454951 @default.
- W1571973263 hasConceptScore W1571973263C110586980 @default.
- W1571973263 hasConceptScore W1571973263C126322002 @default.
- W1571973263 hasConceptScore W1571973263C134018914 @default.
- W1571973263 hasConceptScore W1571973263C142724271 @default.
- W1571973263 hasConceptScore W1571973263C164705383 @default.
- W1571973263 hasConceptScore W1571973263C204787440 @default.
- W1571973263 hasConceptScore W1571973263C2777622882 @default.
- W1571973263 hasConceptScore W1571973263C2778326061 @default.
- W1571973263 hasConceptScore W1571973263C2908647359 @default.
- W1571973263 hasConceptScore W1571973263C42219234 @default.
- W1571973263 hasConceptScore W1571973263C519581460 @default.
- W1571973263 hasConceptScore W1571973263C71924100 @default.
- W1571973263 hasConceptScore W1571973263C90924648 @default.
- W1571973263 hasConceptScore W1571973263C99454951 @default.
- W1571973263 hasLocation W15719732631 @default.
- W1571973263 hasOpenAccess W1571973263 @default.
- W1571973263 hasPrimaryLocation W15719732631 @default.
- W1571973263 hasRelatedWork W1564375672 @default.
- W1571973263 hasRelatedWork W1591604414 @default.
- W1571973263 hasRelatedWork W1968256719 @default.
- W1571973263 hasRelatedWork W1980566770 @default.
- W1571973263 hasRelatedWork W1989005121 @default.
- W1571973263 hasRelatedWork W2003149028 @default.
- W1571973263 hasRelatedWork W2009014799 @default.
- W1571973263 hasRelatedWork W2009609368 @default.
- W1571973263 hasRelatedWork W2011190444 @default.
- W1571973263 hasRelatedWork W2040501976 @default.
- W1571973263 hasRelatedWork W2049105133 @default.
- W1571973263 hasRelatedWork W2141602597 @default.
- W1571973263 hasRelatedWork W2287077457 @default.
- W1571973263 hasRelatedWork W2330044328 @default.
- W1571973263 hasRelatedWork W238663572 @default.
- W1571973263 hasRelatedWork W2811123000 @default.
- W1571973263 hasRelatedWork W2886391754 @default.
- W1571973263 hasRelatedWork W2903873335 @default.
- W1571973263 hasRelatedWork W2921379115 @default.
- W1571973263 hasRelatedWork W3210188539 @default.
- W1571973263 hasVolume "130" @default.
- W1571973263 isParatext "false" @default.
- W1571973263 isRetracted "false" @default.
- W1571973263 magId "1571973263" @default.
- W1571973263 workType "article" @default.