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- W1572034002 abstract "A drug carrier particle, through its morphology and surface properties, influences the performance of dry powder for inhalation. Particles made of lactose and lactose with small amounts of lung compatible surfactants (LCS) were fabricated by spray drying of aqueous solutions sprayed in an ultrasonic nebulizer. Obtained lactose/LCS particles were non-spherical with puff-like morphology in contrast to smoothsurface spherical particles of pure lactose. The composite powder dissolved in water strongly reduced dynamic surface tension, indicating that the mass of LCS incorporated with a particle was probably much higher than the one resulting from the theoretical mass balance. It may be caused by affinity between surfactant molecules and lactose, but also by the synergy in surface tension reduction. Experimental reentrainment of both types of powders in the inhaler showed that the efficiency of the aerosolization process was noticeably increased for composite particles. It is explained by the reduction of adhesive forces due to steric hindering effect caused by long chain surfactant molecules present on the surface of composite particles. In conclusion, lactose/LCS composite particles formed by spray drying can be efficient carriers of inhalation drugs with an additional beneficial function caused by the simultaneous delivery of surfactant." @default.
- W1572034002 created "2016-06-24" @default.
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- W1572034002 date "2010-01-01" @default.
- W1572034002 modified "2023-10-11" @default.
- W1572034002 title "Aerosolization and surface properties of a composite powder drug carrier" @default.
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