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- W1572050003 abstract "The problems associated with neglected diseases are often compounded by increasing incidence of antibiotic resistance. Patient negligence and abuse of antibiotics has lead to explosive growth in cases of tuberculosis, with some M. tuberculosis strains becoming virtually untreatable. Structure-based drug development is viewed as cost-effective and time-consuming method for discovery and development of hits to lead compounds. In this review we will discuss the suitability of fragment-based methods for developing new chemotherapeutics against neglected diseases, providing examples from our tuberculosis programme." @default.
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- W1572050003 date "2009-01-01" @default.
- W1572050003 modified "2023-09-26" @default.
- W1572050003 title "Fragment-Based Drug Discovery in Academia: Experiences From a Tuberculosis Programme" @default.
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- W1572050003 doi "https://doi.org/10.1007/978-90-481-2339-1_3" @default.
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