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- W1572078652 abstract "This chapter describes the genetics of multiple sclerosis (MS). MS mainly affects Caucasians, and although the disease clusters in families, inheritance does not follow the clear Mendelian patterns of monogenic disease. Estimates of familial recurrence risks and independent molecular studies indicate that several genes act together in conferring susceptibility, with each having only a modest individual effect. Although it is well established that genetic factors interact with unknown environmental triggers, the relative importance of these factors and their overall contribution to MS and susceptibility in the individual are still debated, especially in the context of disease heterogeneity. Previous attempts to identify relevant genes have highlighted the role of the major histocompatibility complex (MHC) but so far have failed unequivocally to implicate other candidate genes. The development of new technologies for genetic analysis has allowed the completion of six systematic linkage-based whole genome screens in different populations, identifying several potential regions of chromosomal interest." @default.
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- W1572078652 date "2003-01-01" @default.
- W1572078652 modified "2023-10-18" @default.
- W1572078652 title "Chapter 6 Genetics of Multiple Sclerosis" @default.
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- W1572078652 doi "https://doi.org/10.1016/s1877-3419(09)70035-2" @default.
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