FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572125866> ?p ?o ?g. }

• W1572125866 endingPage "S89" @default.
• W1572125866 startingPage "S82" @default.
• W1572125866 abstract "The cytochromes P450 (CYPs) comprise a vast superfamily of enzymes found in virtually all life forms. In mammals, xenobiotic metabolizing CYPs provide crucial protection from the effects of exposure to a wide variety of chemicals, including environmental toxins and therapeutic drugs. Ideally, the information on the possible metabolism by CYPs required during drug development would be obtained from crystal structures of all the CYPs of interest. For some years only crystal structures of distantly related bacterial CYPs were available and homology modelling techniques were used to bridge the gap and produce structural models of human CYPs, and thereby obtain useful functional information. A significant step forward in the reliability of these models came seven years ago with the first crystal structure of a mammalian CYP, rabbit CYP2C5, followed by the structures of six human enzymes, CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6 and CYP3A4, and a second rabbit enzyme, CYP2B4. In this review we describe as a case study the evolution of a CYP2D6 model, leading to the validation of the model as an in silico tool for predicting binding and metabolism. This work has led directly to the successful design of CYP2D6 mutants with novel activity-including creating a testosterone hydroxylase, converting quinidine from inhibitor to substrate, creating a diclofenac hydroxylase and creating a dextromethorphan O-demethylase. Our modelling-derived hypothesis-driven integrated interdisciplinary studies have given key insight into the molecular determinants of CYP2D6 and other important drug metabolizing enzymes." @default.
• W1572125866 created "2016-06-24" @default.
• W1572125866 creator A5011180529 @default.
• W1572125866 creator A5042152474 @default.
• W1572125866 creator A5075553035 @default.
• W1572125866 creator A5076914476 @default.
• W1572125866 creator A5087375405 @default.
• W1572125866 creator A5090419414 @default.
• W1572125866 date "2008-03-01" @default.
• W1572125866 modified "2023-09-28" @default.
• W1572125866 title "Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions" @default.
• W1572125866 cites W1498652161 @default.
• W1572125866 cites W1508885706 @default.
• W1572125866 cites W1527820925 @default.
• W1572125866 cites W1757299784 @default.
• W1572125866 cites W1969695802 @default.
• W1572125866 cites W1970009415 @default.
• W1572125866 cites W1974543768 @default.
• W1572125866 cites W1975206909 @default.
• W1572125866 cites W1980128327 @default.
• W1572125866 cites W1981046943 @default.
• W1572125866 cites W1985945621 @default.
• W1572125866 cites W1986743541 @default.
• W1572125866 cites W1988928606 @default.
• W1572125866 cites W1992187482 @default.
• W1572125866 cites W1992679494 @default.
• W1572125866 cites W1992822028 @default.
• W1572125866 cites W1994802228 @default.
• W1572125866 cites W1996286663 @default.
• W1572125866 cites W2000051743 @default.
• W1572125866 cites W2000349963 @default.
• W1572125866 cites W2002779112 @default.
• W1572125866 cites W2010897322 @default.
• W1572125866 cites W2011048896 @default.
• W1572125866 cites W2011258029 @default.
• W1572125866 cites W2012453845 @default.
• W1572125866 cites W2014919794 @default.
• W1572125866 cites W2021232512 @default.
• W1572125866 cites W2021474803 @default.
• W1572125866 cites W2025392650 @default.
• W1572125866 cites W2035091931 @default.
• W1572125866 cites W2039249350 @default.
• W1572125866 cites W2041477433 @default.
• W1572125866 cites W2042738756 @default.
• W1572125866 cites W2044793333 @default.
• W1572125866 cites W2045603507 @default.
• W1572125866 cites W2047924589 @default.
• W1572125866 cites W2050456292 @default.
• W1572125866 cites W2051639214 @default.
• W1572125866 cites W2064926901 @default.
• W1572125866 cites W2065283382 @default.
• W1572125866 cites W2067556491 @default.
• W1572125866 cites W2068802475 @default.
• W1572125866 cites W2069447114 @default.
• W1572125866 cites W2070098436 @default.
• W1572125866 cites W2070429297 @default.
• W1572125866 cites W2073073931 @default.
• W1572125866 cites W2074402745 @default.
• W1572125866 cites W2074648749 @default.
• W1572125866 cites W2078427294 @default.
• W1572125866 cites W2080653934 @default.
• W1572125866 cites W2084686194 @default.
• W1572125866 cites W2089353933 @default.
• W1572125866 cites W2093905655 @default.
• W1572125866 cites W2097799982 @default.
• W1572125866 cites W2101220662 @default.
• W1572125866 cites W2104180764 @default.
• W1572125866 cites W2105587896 @default.
• W1572125866 cites W2106195907 @default.
• W1572125866 cites W2117084688 @default.
• W1572125866 cites W2122103602 @default.
• W1572125866 cites W2127606049 @default.
• W1572125866 cites W2130983257 @default.
• W1572125866 cites W2151774137 @default.
• W1572125866 cites W2151988692 @default.
• W1572125866 cites W2153834789 @default.
• W1572125866 cites W2154598050 @default.
• W1572125866 cites W2156423252 @default.
• W1572125866 cites W2159529011 @default.
• W1572125866 cites W2159677620 @default.
• W1572125866 cites W2329354175 @default.
• W1572125866 cites W2986099433 @default.
• W1572125866 cites W4236830009 @default.
• W1572125866 doi "https://doi.org/10.1038/sj.bjp.0707570" @default.
• W1572125866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268062" @default.
• W1572125866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18026129" @default.
• W1572125866 hasPublicationYear "2008" @default.
• W1572125866 type Work @default.
• W1572125866 sameAs 1572125866 @default.
• W1572125866 citedByCount "40" @default.
• W1572125866 countsByYear W15721258662012 @default.
• W1572125866 countsByYear W15721258662013 @default.
• W1572125866 countsByYear W15721258662014 @default.
• W1572125866 countsByYear W15721258662015 @default.
• W1572125866 countsByYear W15721258662016 @default.
• W1572125866 countsByYear W15721258662018 @default.
• W1572125866 countsByYear W15721258662019 @default.
• W1572125866 countsByYear W15721258662020 @default.

• next