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- W1572138529 abstract "Objectives: Epidemiologists often study the relationship between a susceptibility gene and a disease using the case-control design. Due to stratification/admixture that may exist in the study population, the conventional case-control design may lead to biased estimation of ‘genotype relative risks’(GRRs). This problem can be circumvented by using the ‘case-parental control design’ instead. Under this design, there have been three non-iterative methods for estimating GRRs proposed in the literature. Here we propose a new non-iterative method using the Mantel-Haenszel(MH) concept. Methods: The above four methods have similar formula apar from the weighting constants. The weighting constants used in the M-H method are 1.5 Results: Monte-Carlo simulation shows that the above four methods all produce estimates that are approximately unbiased. However, the M-H method has the smallest variance and hence is the most stable among the four methods. Conclusions: The M-H method is simple to calculated and more stable than the other three non-iterative methods for the estimation of the GRRs in the case-parental control study." @default.
- W1572138529 created "2016-06-24" @default.
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- W1572138529 date "2000-12-01" @default.
- W1572138529 modified "2023-10-08" @default.
- W1572138529 title "病例雙親對照研究法中基因型相對危險性之估計：Mantel-Haenszel法之應用" @default.
- W1572138529 doi "https://doi.org/10.6288/cjph2000-19-06-09" @default.
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