FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572157649> ?p ?o ?g. }

• W1572157649 endingPage "3044" @default.
• W1572157649 startingPage "3030" @default.
• W1572157649 abstract "Citreoviridin (CIT) is a mycotoxin derived from fungal species in moldy cereals. In our previous study, we reported that CIT stimulated autophagosome formation in human liver HepG2 cells. Here, we aimed to explore the relationship of autophagy with lysosomal membrane permeabilization and apoptosis in CIT-treated cells. Our data showed that CIT increased the expression of LC3-II, an autophagosome biomarker, from the early stage of treatment (6 h). After treatment with CIT for 12 h, lysosomal membrane permeabilization occurred, followed by the release of cathepsin D in HepG2 cells. Inhibition of autophagosome formation with siRNA against Atg5 attenuated CIT-induced lysosomal membrane permeabilization. In addition, CIT induced collapse of mitochondrial transmembrane potential as assessed by JC-1 staining. Furthermore, caspase-3 activity assay showed that CIT induced apoptosis in HepG2 cells. Inhibition of autophagosome formation attenuated CIT-induced apoptosis, indicating that CIT-induced apoptosis was autophagy-dependent. Cathepsin D inhibitor, pepstatin A, relieved CIT-induced apoptosis as well, suggesting the involvement of the lysosomal-mitochondrial axis in CIT-induced apoptosis. Taken together, our data demonstrated that CIT induced autophagy-dependent apoptosis through the lysosomal-mitochondrial axis in HepG2 cells. The study thus provides essential mechanistic insight, and suggests clues for the effective management and treatment of CIT-related diseases." @default.
• W1572157649 created "2016-06-24" @default.
• W1572157649 creator A5007269961 @default.
• W1572157649 creator A5012718640 @default.
• W1572157649 creator A5020149556 @default.
• W1572157649 creator A5031399070 @default.
• W1572157649 creator A5044137903 @default.
• W1572157649 creator A5046214507 @default.
• W1572157649 creator A5049716356 @default.
• W1572157649 creator A5064717793 @default.
• W1572157649 creator A5079447763 @default.
• W1572157649 creator A5084959058 @default.
• W1572157649 date "2015-08-06" @default.
• W1572157649 modified "2023-09-26" @default.
• W1572157649 title "Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells" @default.
• W1572157649 cites W1640748843 @default.
• W1572157649 cites W1963574121 @default.
• W1572157649 cites W1963786594 @default.
• W1572157649 cites W1964475578 @default.
• W1572157649 cites W1967408747 @default.
• W1572157649 cites W1972201357 @default.
• W1572157649 cites W1972708772 @default.
• W1572157649 cites W1974115318 @default.
• W1572157649 cites W1979889178 @default.
• W1572157649 cites W1983096387 @default.
• W1572157649 cites W1992637754 @default.
• W1572157649 cites W1998454517 @default.
• W1572157649 cites W2000413234 @default.
• W1572157649 cites W2001675597 @default.
• W1572157649 cites W2005341905 @default.
• W1572157649 cites W2013860497 @default.
• W1572157649 cites W2014368894 @default.
• W1572157649 cites W2027021489 @default.
• W1572157649 cites W2034132952 @default.
• W1572157649 cites W2037082304 @default.
• W1572157649 cites W2045601601 @default.
• W1572157649 cites W2052853384 @default.
• W1572157649 cites W2054580728 @default.
• W1572157649 cites W2059362455 @default.
• W1572157649 cites W2076603762 @default.
• W1572157649 cites W2080878773 @default.
• W1572157649 cites W2088581544 @default.
• W1572157649 cites W2106684995 @default.
• W1572157649 cites W2110048031 @default.
• W1572157649 cites W2113492659 @default.
• W1572157649 cites W2143162047 @default.
• W1572157649 cites W2154125015 @default.
• W1572157649 cites W2157699677 @default.
• W1572157649 cites W2159131006 @default.
• W1572157649 cites W2167049000 @default.
• W1572157649 doi "https://doi.org/10.3390/toxins7083030" @default.
• W1572157649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4549738" @default.
• W1572157649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26258792" @default.
• W1572157649 hasPublicationYear "2015" @default.
• W1572157649 type Work @default.
• W1572157649 sameAs 1572157649 @default.
• W1572157649 citedByCount "25" @default.
• W1572157649 countsByYear W15721576492015 @default.
• W1572157649 countsByYear W15721576492016 @default.
• W1572157649 countsByYear W15721576492017 @default.
• W1572157649 countsByYear W15721576492018 @default.
• W1572157649 countsByYear W15721576492019 @default.
• W1572157649 countsByYear W15721576492020 @default.
• W1572157649 countsByYear W15721576492021 @default.
• W1572157649 countsByYear W15721576492022 @default.
• W1572157649 countsByYear W15721576492023 @default.
• W1572157649 crossrefType "journal-article" @default.
• W1572157649 hasAuthorship W1572157649A5007269961 @default.
• W1572157649 hasAuthorship W1572157649A5012718640 @default.
• W1572157649 hasAuthorship W1572157649A5020149556 @default.
• W1572157649 hasAuthorship W1572157649A5031399070 @default.
• W1572157649 hasAuthorship W1572157649A5044137903 @default.
• W1572157649 hasAuthorship W1572157649A5046214507 @default.
• W1572157649 hasAuthorship W1572157649A5049716356 @default.
• W1572157649 hasAuthorship W1572157649A5064717793 @default.
• W1572157649 hasAuthorship W1572157649A5079447763 @default.
• W1572157649 hasAuthorship W1572157649A5084959058 @default.
• W1572157649 hasBestOaLocation W15721576491 @default.
• W1572157649 hasConcept C153911025 @default.
• W1572157649 hasConcept C167844969 @default.
• W1572157649 hasConcept C168296220 @default.
• W1572157649 hasConcept C173633252 @default.
• W1572157649 hasConcept C181199279 @default.
• W1572157649 hasConcept C185592680 @default.
• W1572157649 hasConcept C190283241 @default.
• W1572157649 hasConcept C203522944 @default.
• W1572157649 hasConcept C2776350231 @default.
• W1572157649 hasConcept C2776714187 @default.
• W1572157649 hasConcept C2777135640 @default.
• W1572157649 hasConcept C2780216420 @default.
• W1572157649 hasConcept C2781000418 @default.
• W1572157649 hasConcept C28021979 @default.
• W1572157649 hasConcept C28859421 @default.
• W1572157649 hasConcept C55493867 @default.
• W1572157649 hasConcept C86803240 @default.
• W1572157649 hasConcept C88634738 @default.
• W1572157649 hasConcept C95444343 @default.
• W1572157649 hasConceptScore W1572157649C153911025 @default.

• next