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• W1572158173 abstract "The nerve growth factor NGF belongs to the neurotrophin family and was described for the first time more than fifty years ago by Rita Levi-Montalcini and collaborators (LeviMontalcini et al., 1995; Levi-Montalcini & Hamburger, 1951), who showed its major role in neuronal growth and survival. NGF effects are mediated by activation of two receptor types: the low-affinity p75 receptor for neurotrophins (p75NTR) and the high-affinity tropomyosinrelated kinase A (TrkA) receptor (Freund-Michel & Frossard, 2008a). The p75NTR receptor belongs to the death receptor family and its activation by NGF at nanomolar concentrations leads either to proor anti-apoptotic signalling pathways. The p75NTR receptor is not selective for NGF as it can also bind pro-neurotrophins and the other neurotrophins at the same nanomolar concentrations (Chao, 2003). Inversely, the TrkA receptor is selective for NGF and belongs to the tyrosine-kinase receptor family. Its activation by NGF at picomolar concentrations activates signalling pathways inducing cell proliferation, differentiation and survival in particular through activation of phosphatidylinositol-3 kinase (PI3K), small protein G Ras, phospholipase C (PLC) and mitogen-activated protein kinases (MAPK) (Freund-Michel & Frossard, 2008a). The role of NGF in neuronal growth and survival has been widely studied and led to consider NGF as a promising therapeutic target in several pathologies of the nervous system, in particular neurodegenerative diseases (Prakash et al., 2010). In addition, many studies have suggested that NGF also plays the role of an inflammatory mediator, in particular in the lung (Freund-Michel & Frossard, 2008a). Indeed, numerous sources of NGF have been described in the lung, including infiltrated inflammatory cells, sensory nerves, and many lung structural cells such as fibroblasts, epithelial, endothelial, and" @default.
• W1572158173 created "2016-06-24" @default.
• W1572158173 creator A5028540712 @default.
• W1572158173 creator A5034320932 @default.
• W1572158173 creator A5084036027 @default.
• W1572158173 date "2011-12-16" @default.
• W1572158173 modified "2023-09-30" @default.
• W1572158173 title "Expression and Role of the TrkA Receptor in Pulmonary Inflammatory Diseases" @default.
• W1572158173 cites W144346233 @default.
• W1572158173 cites W1512083342 @default.
• W1572158173 cites W1519434477 @default.
• W1572158173 cites W1533227151 @default.
• W1572158173 cites W1554206058 @default.
• W1572158173 cites W1563534485 @default.
• W1572158173 cites W1566175888 @default.
• W1572158173 cites W1574914587 @default.
• W1572158173 cites W1578330658 @default.
• W1572158173 cites W1602494224 @default.
• W1572158173 cites W1684287923 @default.
• W1572158173 cites W1826590371 @default.
• W1572158173 cites W1857341105 @default.
• W1572158173 cites W1913583396 @default.
• W1572158173 cites W1963076750 @default.
• W1572158173 cites W1964325390 @default.
• W1572158173 cites W1964989035 @default.
• W1572158173 cites W1969349734 @default.
• W1572158173 cites W1975686672 @default.
• W1572158173 cites W1975970697 @default.
• W1572158173 cites W1979918788 @default.
• W1572158173 cites W1984509724 @default.
• W1572158173 cites W1984708466 @default.
• W1572158173 cites W1984754427 @default.
• W1572158173 cites W1985089425 @default.
• W1572158173 cites W1987182835 @default.
• W1572158173 cites W1989588869 @default.
• W1572158173 cites W1990629997 @default.
• W1572158173 cites W1993156594 @default.
• W1572158173 cites W1994081545 @default.
• W1572158173 cites W1994993130 @default.
• W1572158173 cites W1997341361 @default.
• W1572158173 cites W1997683044 @default.
• W1572158173 cites W2004047981 @default.
• W1572158173 cites W2004303128 @default.
• W1572158173 cites W2011188068 @default.
• W1572158173 cites W2012423618 @default.
• W1572158173 cites W2012779735 @default.
• W1572158173 cites W2012839323 @default.
• W1572158173 cites W2013249463 @default.
• W1572158173 cites W2016233008 @default.
• W1572158173 cites W2017907021 @default.
• W1572158173 cites W2019481374 @default.
• W1572158173 cites W2019559069 @default.
• W1572158173 cites W2019639349 @default.
• W1572158173 cites W2019843044 @default.
• W1572158173 cites W2020902418 @default.
• W1572158173 cites W2023397379 @default.
• W1572158173 cites W2024510822 @default.
• W1572158173 cites W2025593289 @default.
• W1572158173 cites W2027688281 @default.
• W1572158173 cites W2029328864 @default.
• W1572158173 cites W2032348377 @default.
• W1572158173 cites W2034507812 @default.
• W1572158173 cites W2034673017 @default.
• W1572158173 cites W2036139175 @default.
• W1572158173 cites W2037831105 @default.
• W1572158173 cites W2040620685 @default.
• W1572158173 cites W2042447045 @default.
• W1572158173 cites W2043429832 @default.
• W1572158173 cites W2043535624 @default.
• W1572158173 cites W2044404946 @default.
• W1572158173 cites W2047024992 @default.
• W1572158173 cites W2048347552 @default.
• W1572158173 cites W2055804358 @default.
• W1572158173 cites W2056447915 @default.
• W1572158173 cites W2057189159 @default.
• W1572158173 cites W2057274284 @default.
• W1572158173 cites W2057377879 @default.
• W1572158173 cites W2058199689 @default.
• W1572158173 cites W2058987172 @default.
• W1572158173 cites W2059524959 @default.
• W1572158173 cites W2060411448 @default.
• W1572158173 cites W2062002285 @default.
• W1572158173 cites W2062514032 @default.
• W1572158173 cites W2063107527 @default.
• W1572158173 cites W2064265756 @default.
• W1572158173 cites W2065098417 @default.
• W1572158173 cites W2066121105 @default.
• W1572158173 cites W2066802006 @default.
• W1572158173 cites W2067523166 @default.
• W1572158173 cites W2067793380 @default.
• W1572158173 cites W2068828701 @default.
• W1572158173 cites W2070325241 @default.
• W1572158173 cites W2070817288 @default.
• W1572158173 cites W2071227662 @default.
• W1572158173 cites W2071867041 @default.
• W1572158173 cites W2073611916 @default.
• W1572158173 cites W2074514459 @default.
• W1572158173 cites W2074904685 @default.
• W1572158173 cites W2075330152 @default.
• W1572158173 cites W2075503261 @default.

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