Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572178758> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1572178758 endingPage "11013" @default.
- W1572178758 startingPage "11009" @default.
- W1572178758 abstract "Abstract Periodate-oxidized adenosine triphosphate (o-ATP), a ribose ring-opened dialdehyde derivative of ATP, reacts specifically with human deoxyhemoglobin to give a single major covalently modified product after reduction with sodium borohydride. This product, designated di-ATP Hb, was isolated using ion-exchange chromatography and shown to have incorporated two molecules of o-ATP/tetramer. Peptide mapping and x-ray crystallography at 2.8-A resolution indicate that a covalent adduct is formed between the ligand and residues Lys-82 EF6 of each beta chain in the organic phosphate-binding site of the molecule. di-ATP Hb exhibits a significantly decreased oxygen affinity (P50 = 20.8 mm Hg versus 5.8 mm Hg control; 50 mM 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-propane-1,3-diol, pH 7.4, 0.1 M C, 20 degrees C). The subunit cooper-activity of di-ATP Hb is also reduced (nmax = 1.9 versus 2.7 control)." @default.
- W1572178758 created "2016-06-24" @default.
- W1572178758 creator A5007883379 @default.
- W1572178758 creator A5008579409 @default.
- W1572178758 creator A5026091071 @default.
- W1572178758 creator A5029427321 @default.
- W1572178758 creator A5052963169 @default.
- W1572178758 date "1989-07-01" @default.
- W1572178758 modified "2023-09-26" @default.
- W1572178758 title "Structure and Function of Human Hemoglobin Covalently Labeled with Periodate-oxidized Adenosine Triphosphate" @default.
- W1572178758 cites W1191012606 @default.
- W1572178758 cites W1530712175 @default.
- W1572178758 cites W1692953736 @default.
- W1572178758 cites W1969054447 @default.
- W1572178758 cites W1969467289 @default.
- W1572178758 cites W1994647181 @default.
- W1572178758 cites W2005436544 @default.
- W1572178758 cites W2006672992 @default.
- W1572178758 cites W2027643131 @default.
- W1572178758 cites W2035012941 @default.
- W1572178758 cites W2039087718 @default.
- W1572178758 cites W2043170034 @default.
- W1572178758 cites W2059179869 @default.
- W1572178758 cites W2077798719 @default.
- W1572178758 cites W2079117840 @default.
- W1572178758 cites W2084134870 @default.
- W1572178758 cites W2100837269 @default.
- W1572178758 cites W2125087906 @default.
- W1572178758 cites W2777982 @default.
- W1572178758 doi "https://doi.org/10.1016/s0021-9258(18)60419-3" @default.
- W1572178758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2544579" @default.
- W1572178758 hasPublicationYear "1989" @default.
- W1572178758 type Work @default.
- W1572178758 sameAs 1572178758 @default.
- W1572178758 citedByCount "3" @default.
- W1572178758 crossrefType "journal-article" @default.
- W1572178758 hasAuthorship W1572178758A5007883379 @default.
- W1572178758 hasAuthorship W1572178758A5008579409 @default.
- W1572178758 hasAuthorship W1572178758A5026091071 @default.
- W1572178758 hasAuthorship W1572178758A5029427321 @default.
- W1572178758 hasAuthorship W1572178758A5052963169 @default.
- W1572178758 hasBestOaLocation W15721787581 @default.
- W1572178758 hasConcept C14036430 @default.
- W1572178758 hasConcept C178790620 @default.
- W1572178758 hasConcept C180577832 @default.
- W1572178758 hasConcept C185592680 @default.
- W1572178758 hasConcept C2776789926 @default.
- W1572178758 hasConcept C2778917026 @default.
- W1572178758 hasConcept C2779564974 @default.
- W1572178758 hasConcept C55493867 @default.
- W1572178758 hasConcept C86803240 @default.
- W1572178758 hasConcept C95444343 @default.
- W1572178758 hasConceptScore W1572178758C14036430 @default.
- W1572178758 hasConceptScore W1572178758C178790620 @default.
- W1572178758 hasConceptScore W1572178758C180577832 @default.
- W1572178758 hasConceptScore W1572178758C185592680 @default.
- W1572178758 hasConceptScore W1572178758C2776789926 @default.
- W1572178758 hasConceptScore W1572178758C2778917026 @default.
- W1572178758 hasConceptScore W1572178758C2779564974 @default.
- W1572178758 hasConceptScore W1572178758C55493867 @default.
- W1572178758 hasConceptScore W1572178758C86803240 @default.
- W1572178758 hasConceptScore W1572178758C95444343 @default.
- W1572178758 hasIssue "19" @default.
- W1572178758 hasLocation W15721787581 @default.
- W1572178758 hasLocation W15721787582 @default.
- W1572178758 hasOpenAccess W1572178758 @default.
- W1572178758 hasPrimaryLocation W15721787581 @default.
- W1572178758 hasRelatedWork W1572178758 @default.
- W1572178758 hasRelatedWork W1984229353 @default.
- W1572178758 hasRelatedWork W1990563422 @default.
- W1572178758 hasRelatedWork W1997395984 @default.
- W1572178758 hasRelatedWork W2049070036 @default.
- W1572178758 hasRelatedWork W2342892412 @default.
- W1572178758 hasRelatedWork W2396088238 @default.
- W1572178758 hasRelatedWork W2950577719 @default.
- W1572178758 hasRelatedWork W2951845488 @default.
- W1572178758 hasRelatedWork W4251902799 @default.
- W1572178758 hasVolume "264" @default.
- W1572178758 isParatext "false" @default.
- W1572178758 isRetracted "false" @default.
- W1572178758 magId "1572178758" @default.
- W1572178758 workType "article" @default.