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• W1572202501 abstract "In the pathogenic yeast Candida glabrata, multidrug resistance is associated with the overexpression of drug efflux pumps caused by gain-of-function mutations in the CgPDR1 gene. CgPdr1p transcription factor, which activates the expression of several drug efflux transporter genes, is considered to be a promising target for compounds sensitizing the multidrug-resistant yeast cells. Here, we describe a cell-based screening system for detecting the inhibitory activity of compounds interfering with the CgPdr1p function in a heterologous genetic background of the hypersensitive Saccharomyces cerevisiae mutant strain. The screening is based on the ability to abrogate the growth defect of cells suffering from the galactose-induced and CgPdr1p-driven overexpression of a dominant lethal pma1(D378N) allele placed under the control of the ScPDR5 promoter. The system allows rapid identification of multidrug resistance reversal agents inhibiting the CgPdr1p activity or loss-of-function Cgpdr1 mutations, and is amenable to high-throughput screening on solid or liquid media." @default.
• W1572202501 created "2016-06-24" @default.
• W1572202501 creator A5039063686 @default.
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• W1572202501 date "2010-12-03" @default.
• W1572202501 modified "2023-09-25" @default.
• W1572202501 title "A yeast cell-based system for screening Candida glabrata multidrug resistance reversal agents and selection of loss-of-function pdr1 mutants" @default.
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• W1572202501 doi "https://doi.org/10.1111/j.1567-1364.2010.00702.x" @default.
• W1572202501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21129149" @default.
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