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- W1572218605 abstract "We investigate the key characteristics of Ca2+ puffs in deterministic and stochastic frameworks that all incorporate the cellular morphology of IP3 receptor channel clusters. In the first step, we numerically study the Ca2+ liberation in a three-dimensional representation of a cluster environment with reaction-diffusion dynamics in both the cytosol and the lumen. These simulations reveal that Ca2+ concentrations at a releasing cluster range from 80 to 170 μM and equilibrate almost instantaneously on the time scale of the release duration. These highly elevated Ca2+ concentrations eliminate Ca2+ oscillations in a deterministic model of an IP3R channel cluster at physiological parameter values as revealed by a linear stability analysis. The reason lies in the saturation of all feedback processes in the IP3R gating dynamics, so that only fluctuations can restore experimentally observed Ca2+ oscillations. In this spirit, we derive master equations that allow us to analytically quantify the onset of Ca2+ puffs and hence the stochastic time scale of intracellular Ca2+ dynamics. Moving up the spatial scale, we suggest to formulate cellular dynamics in terms of waiting time distribution functions. This approach prevents the state space explosion that is typical for the description of cellular dynamics based on channel states and still contains information on molecular fluctuations. We illustrate this method by studying global Ca2+ oscillations." @default.
- W1572218605 created "2016-06-24" @default.
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- W1572218605 date "2009-09-01" @default.
- W1572218605 modified "2023-10-12" @default.
- W1572218605 title "Toward a predictive model of Ca2+ puffs" @default.
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- W1572218605 doi "https://doi.org/10.1063/1.3183809" @default.
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