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- W1572316274 abstract "Phylogeny indicates that in mammals memory CD4-dependent antibody responses evolved after monotremes split from the common ancestor of marsupial and eutherian mammals. This was strongly associated with the development of segregated B and T cell areas and the development of a linked lymph node network. The evolution of the lymphotoxin beta receptor in these higher mammals was key to the development of these new functions. Here, we argue that lymphoid tissue inducer cells played a pivotal role not only in the development of organized lymphoid structures but also in the subsequent genesis of the CD4-dependent class-switched memory antibody responses that depend on an organized infrastructure to work. In this review, we concentrate on the role of this cell type in the making of a tolerant CD4 T cell repertoire and in the sustenance of CD4 T cell responses for protective immunity." @default.
- W1572316274 created "2016-06-24" @default.
- W1572316274 creator A5009322753 @default.
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- W1572316274 creator A5038212214 @default.
- W1572316274 creator A5039257689 @default.
- W1572316274 creator A5039762924 @default.
- W1572316274 date "2010-01-01" @default.
- W1572316274 modified "2023-09-28" @default.
- W1572316274 title "Lymphoid Tissue Inducer Cells and the Evolution of CD4 Dependent High-Affinity Antibody Responses" @default.
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- W1572316274 doi "https://doi.org/10.1016/s1877-1173(10)92007-3" @default.
- W1572316274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20800820" @default.
- W1572316274 hasPublicationYear "2010" @default.
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