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• W1572317967 abstract "In mammalian testis, spermatogenesis takes place in the seminiferous epithelium of the seminiferous tubule, which is composed of a series of cellular events. These include: (i) spermatogonial stem cell (SSC) renewal via mitosis and differentiation of SSC to spermatogenia, (ii) meiosis, (iii) spermiogenesis, and (iv) spermiation. Throughout these events, developing germ cells remain adhered to the Sertoli cell in the seminiferous epithelium amidst extensive cellular, biochemical, molecular and morphological changes to obtain structural support and nourishment. These events are coordinated via signal transduction at the cell-cell interface through cell junctions, illustrating the significance of cell junctions and adhesion in spermatogenesis. Additionally, developing germ cells migrate progressively across the seminiferous epithelium from the stem cell niche, which is located in the basal compartment near the basement membrane of the tunica propria adjacent to the interstitium. Recent studies have shown that some apparently unrelated proteins, such as polarity proteins and actin regulatory proteins, are in fact working in concert and synergistically to coordinate the continuous cyclic changes of adhesion at the Sertoli-Sertoli and Sertoli-germ cell interface in the seminiferous epithelium during the epithelial cycle of spermatogenesis, such that developing germ cells remain attached to the Sertoli cell in the epithelium while they alter in cell shape and migrate across the epithelium. In this review, we highlight the physiological significance of endocytic vesicle-mediated protein trafficking events under the influence of polarity and actin regulatory proteins in conferring cyclic events of cell adhesion and de-adhesion. Furthermore, these recent findings have unraveled some unexpected molecules to be targeted for male contraceptive development, which are also targets of toxicant-induced male reproductive dysfunction." @default.
• W1572317967 created "2016-06-24" @default.
• W1572317967 creator A5000133136 @default.
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• W1572317967 creator A5066071162 @default.
• W1572317967 creator A5073736272 @default.
• W1572317967 date "2011-11-01" @default.
• W1572317967 modified "2023-09-23" @default.
• W1572317967 title "Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis." @default.
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• W1572317967 doi "https://doi.org/10.14670/hh-26.1465" @default.
• W1572317967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4059515" @default.
• W1572317967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21938683" @default.
• W1572317967 hasPublicationYear "2011" @default.
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