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- W157234076 abstract "Evidence has been presented supporting the concept of a of certain sugars into calf and rat lenses. This conclusion was reached from observation of structural requirements for entry of closely related sugars into calf lens, and from a kinetic analysis of the entry of sugars into the rat lens. At high sugar concentrations, saturation of the binding sites and competition between pairs of monosaccharides were demonstrable in the rat lens. Galactose appeared to have the potentiality of penetrating the cells of the rat lens by simple diffusion or by utilizing the binding sites. Glucose and fructose competed for utilization by calf lens with the former appearing to have five to six times the affinity of the latter. A number of carbohydrates apparently pass through the lens capsule but are unable to cross cellular membranes. E, Ifforts to evaluate the uptake of carbohydrates by the lens have been stimulated by the occurrence of diabetic and other forms of sugar cataract, and the recent demonstration of the sorbitol pathway. However, interest has been focused on the metabolism of these substances, and only in the last few years have reports appeared emphasizing the transport of sugars by this tissue. 1 3 Although the processes controlling the movement of sugars across the lenticular membranes are of obvious importance, very little is known concerning them. Detailed investigations have been made on other tissues such as kidney and intestine, both of which accumulate sugars 4 ; and a mediated transfer of monosaccharides has been demonstrated in muscle, erythrocytes, placenta, and tumor cells. 5 The term, me" @default.
- W157234076 created "2016-06-24" @default.
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- W157234076 date "1965-08-01" @default.
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- W157234076 title "THE TRANSPORT OF SUGARS INTO THE LENS." @default.
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