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- W1572414944 abstract "Overexposure to corticosteroid hormones is harmful to hippocampal neuronal integrity, likely by perturbation of calcium homeostasis. To identify molecular mechanisms at the single-cell level, we characterized mRNA expression corresponding to voltage- and ligand-gated Ca channels in individual dissociated CA1 neurons in response to long-term corticosterone (CORT) exposure. Predominant mineralocorticoid receptor occupation (ADC-LO group) resulted in low levels of P/Q- and L-type Ca channel mRNAs, high levels of GluR-2 versus GluR-1, and a high ratio of NMDAR-2A to NMDAR-2B mRNA. Corresponding alterations in protein expression were consistent with the restriction of Ca influx. In contrast, additional glucocorticoid receptor occupation (ADC-HI group) altered the expression of these mRNAs in a manner consistent with enhanced Ca influx; interestingly, qualitatively similar alterations were seen in control ADX neurons. Electrophysiological data from the same neurons indicate that Ca current amplitudes also are modulated by CORT, although on a shorter time scale. Finally, principal components analysis (PCA) suggests that neuronal AMPA and NMDA receptor composition may be regulated by MR and GR activation in a complex manner. Therefore, our data implicate molecular events by which CORT may regulate Ca influx into CA1 hippocampal neurons." @default.
- W1572414944 created "2016-06-24" @default.
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- W1572414944 date "1998-04-01" @default.
- W1572414944 modified "2023-10-18" @default.
- W1572414944 title "Corticosteroid Regulation of Ion Channel Conductances and mRNA Levels in Individual Hippocampal CA1 Neurons" @default.
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- W1572414944 doi "https://doi.org/10.1523/jneurosci.18-07-02685.1998" @default.
- W1572414944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6793106" @default.
- W1572414944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9502826" @default.
- W1572414944 hasPublicationYear "1998" @default.
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