Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572475462> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1572475462 abstract "Abstract WR 40,070 (5-piperonyl-2-4-diaminopyrimidines) was compared with trimethoprim in 4 animal species: mice, rats, rabbits, and dogs. The most important difference between the two compounds uncovered in our investigation is the nature of their cardiac effects. Trimethoprim caused a decrease in cardiac output in the anesthetized dogs whereas WR 40,070 caused an increase. The mechanism responsible for the difference was demonstrated in the dog heart-lung preparation. WR 40,070 caused an improvement in ventricular function by releasing catecholamines. The heart-lung prepared from a dog previously treated with reserpine did not show the cardiac stimulation characteristic of WR 40,070. The transmembrane potential recorded from the isolated rat atrial muscle revealed some changes which suggest that the anti-folic acid activity of this compound and pyrimethamine cause prolongation of repolarization time. The in vitro addition of folic acid caused further prolongation of repolarization time. These changes are not related to the primary changes in contractility and excitability brought about by diaminopyrimidines." @default.
- W1572475462 created "2016-06-24" @default.
- W1572475462 creator A5041303401 @default.
- W1572475462 creator A5045665208 @default.
- W1572475462 creator A5046549761 @default.
- W1572475462 creator A5077921097 @default.
- W1572475462 date "1970-07-01" @default.
- W1572475462 modified "2023-09-27" @default.
- W1572475462 title "Cardiopulmonary effects of antimalarial drugs" @default.
- W1572475462 cites W1971553411 @default.
- W1572475462 cites W1971680493 @default.
- W1572475462 cites W1978156687 @default.
- W1572475462 cites W1991546492 @default.
- W1572475462 cites W2013879807 @default.
- W1572475462 cites W2024236563 @default.
- W1572475462 cites W2032381014 @default.
- W1572475462 cites W2034374996 @default.
- W1572475462 cites W2038613652 @default.
- W1572475462 cites W2046684561 @default.
- W1572475462 cites W2067986188 @default.
- W1572475462 cites W2075976301 @default.
- W1572475462 cites W2161063507 @default.
- W1572475462 cites W2316282107 @default.
- W1572475462 cites W2322813920 @default.
- W1572475462 cites W2334735170 @default.
- W1572475462 cites W2397071326 @default.
- W1572475462 cites W1493032932 @default.
- W1572475462 doi "https://doi.org/10.1016/0041-008x(70)90138-9" @default.
- W1572475462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5456632" @default.
- W1572475462 hasPublicationYear "1970" @default.
- W1572475462 type Work @default.
- W1572475462 sameAs 1572475462 @default.
- W1572475462 citedByCount "5" @default.
- W1572475462 crossrefType "journal-article" @default.
- W1572475462 hasAuthorship W1572475462A5041303401 @default.
- W1572475462 hasAuthorship W1572475462A5045665208 @default.
- W1572475462 hasAuthorship W1572475462A5046549761 @default.
- W1572475462 hasAuthorship W1572475462A5077921097 @default.
- W1572475462 hasConcept C126322002 @default.
- W1572475462 hasConcept C134018914 @default.
- W1572475462 hasConcept C146403970 @default.
- W1572475462 hasConcept C185263204 @default.
- W1572475462 hasConcept C185592680 @default.
- W1572475462 hasConcept C203014093 @default.
- W1572475462 hasConcept C24998067 @default.
- W1572475462 hasConcept C2777035104 @default.
- W1572475462 hasConcept C2777338454 @default.
- W1572475462 hasConcept C2777425658 @default.
- W1572475462 hasConcept C2777714996 @default.
- W1572475462 hasConcept C2777842393 @default.
- W1572475462 hasConcept C2778048844 @default.
- W1572475462 hasConcept C2780728791 @default.
- W1572475462 hasConcept C29730261 @default.
- W1572475462 hasConcept C39133596 @default.
- W1572475462 hasConcept C501593827 @default.
- W1572475462 hasConcept C55493867 @default.
- W1572475462 hasConcept C71924100 @default.
- W1572475462 hasConcept C98274493 @default.
- W1572475462 hasConceptScore W1572475462C126322002 @default.
- W1572475462 hasConceptScore W1572475462C134018914 @default.
- W1572475462 hasConceptScore W1572475462C146403970 @default.
- W1572475462 hasConceptScore W1572475462C185263204 @default.
- W1572475462 hasConceptScore W1572475462C185592680 @default.
- W1572475462 hasConceptScore W1572475462C203014093 @default.
- W1572475462 hasConceptScore W1572475462C24998067 @default.
- W1572475462 hasConceptScore W1572475462C2777035104 @default.
- W1572475462 hasConceptScore W1572475462C2777338454 @default.
- W1572475462 hasConceptScore W1572475462C2777425658 @default.
- W1572475462 hasConceptScore W1572475462C2777714996 @default.
- W1572475462 hasConceptScore W1572475462C2777842393 @default.
- W1572475462 hasConceptScore W1572475462C2778048844 @default.
- W1572475462 hasConceptScore W1572475462C2780728791 @default.
- W1572475462 hasConceptScore W1572475462C29730261 @default.
- W1572475462 hasConceptScore W1572475462C39133596 @default.
- W1572475462 hasConceptScore W1572475462C501593827 @default.
- W1572475462 hasConceptScore W1572475462C55493867 @default.
- W1572475462 hasConceptScore W1572475462C71924100 @default.
- W1572475462 hasConceptScore W1572475462C98274493 @default.
- W1572475462 hasLocation W15724754621 @default.
- W1572475462 hasLocation W15724754622 @default.
- W1572475462 hasOpenAccess W1572475462 @default.
- W1572475462 hasPrimaryLocation W15724754621 @default.
- W1572475462 hasRelatedWork W1572475462 @default.
- W1572475462 hasRelatedWork W1981630754 @default.
- W1572475462 hasRelatedWork W1984541950 @default.
- W1572475462 hasRelatedWork W2021817647 @default.
- W1572475462 hasRelatedWork W2030738332 @default.
- W1572475462 hasRelatedWork W2054992011 @default.
- W1572475462 hasRelatedWork W2064416809 @default.
- W1572475462 hasRelatedWork W2094392260 @default.
- W1572475462 hasRelatedWork W2408603747 @default.
- W1572475462 hasRelatedWork W2899084033 @default.
- W1572475462 isParatext "false" @default.
- W1572475462 isRetracted "false" @default.
- W1572475462 magId "1572475462" @default.
- W1572475462 workType "article" @default.