Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572608034> ?p ?o ?g. }
- W1572608034 endingPage "174" @default.
- W1572608034 startingPage "163" @default.
- W1572608034 abstract "Antipsychotics, risperidone, and risperidone's active metabolite, paliperidone (9-hydroxyrisperidone), are related molecules used for the treatment of schizophrenia and related disorders. Differences in receptor binding, 5-HT2A/D2 (serotonin/dopamine) binding ratios, and mitochondrial proteomics suggest that the effects of risperidone and paliperidone on neuronal firing, regulation of mitochondrial function, and movement are different. This review seeks to explore the most significant differences at the molecular level between risperidone and paliperidone, as reported in preclinical studies. Although risperidone shows higher affinity for 5-HT receptors, paliperidone does not fit this profile. Thus, the risperidone 5-HT2A/D2 binding ratio is significantly lower than the paliperidone 5-HT2A/D2 binding ratio. Paliperidone, similar to lithium and valproate, affects expression levels and phosphorylation of complex I and V proteins in synaptoneurosomal preparations of rat prefrontal cortex, suggesting that paliperidone behaves as a mood stabilizer. It is apparent that the presence of a hydroxyl group in the paliperidone molecule confers increased hydrophilicity to this drug compared with its parent, risperidone; thus, this contributes to differential effects on mitochondrial movement, protein expression, and phosphorylation. These differences are reflected in synaptic plasticity and neuronal firing and have only recently been implicated in the mechanisms of mitochondrial function and movement." @default.
- W1572608034 created "2016-06-24" @default.
- W1572608034 creator A5085591276 @default.
- W1572608034 date "2015-05-06" @default.
- W1572608034 modified "2023-10-14" @default.
- W1572608034 title "Comparative Pharmacology of Risperidone and Paliperidone" @default.
- W1572608034 cites W1484794648 @default.
- W1572608034 cites W1542898773 @default.
- W1572608034 cites W1585966888 @default.
- W1572608034 cites W1709577223 @default.
- W1572608034 cites W1956321811 @default.
- W1572608034 cites W1964936180 @default.
- W1572608034 cites W1968223004 @default.
- W1572608034 cites W1971371348 @default.
- W1572608034 cites W1972159732 @default.
- W1572608034 cites W1978969846 @default.
- W1572608034 cites W1979700184 @default.
- W1572608034 cites W1980722494 @default.
- W1572608034 cites W1985517071 @default.
- W1572608034 cites W1986651279 @default.
- W1572608034 cites W1987161822 @default.
- W1572608034 cites W1990474450 @default.
- W1572608034 cites W1991218028 @default.
- W1572608034 cites W1992644532 @default.
- W1572608034 cites W1993112758 @default.
- W1572608034 cites W1996392427 @default.
- W1572608034 cites W1996617551 @default.
- W1572608034 cites W2000169164 @default.
- W1572608034 cites W2003861928 @default.
- W1572608034 cites W2005294760 @default.
- W1572608034 cites W2007398656 @default.
- W1572608034 cites W2015529691 @default.
- W1572608034 cites W2016493773 @default.
- W1572608034 cites W2018753024 @default.
- W1572608034 cites W2018943698 @default.
- W1572608034 cites W2037533065 @default.
- W1572608034 cites W2050689607 @default.
- W1572608034 cites W2055572268 @default.
- W1572608034 cites W2060035717 @default.
- W1572608034 cites W2061191067 @default.
- W1572608034 cites W2061485615 @default.
- W1572608034 cites W2061850641 @default.
- W1572608034 cites W2063392573 @default.
- W1572608034 cites W2076147139 @default.
- W1572608034 cites W2078872247 @default.
- W1572608034 cites W2087732286 @default.
- W1572608034 cites W2088676377 @default.
- W1572608034 cites W2091017864 @default.
- W1572608034 cites W2092118786 @default.
- W1572608034 cites W2098164623 @default.
- W1572608034 cites W2099483065 @default.
- W1572608034 cites W2108141803 @default.
- W1572608034 cites W2113418300 @default.
- W1572608034 cites W2114098531 @default.
- W1572608034 cites W2122359741 @default.
- W1572608034 cites W2125748363 @default.
- W1572608034 cites W2127624653 @default.
- W1572608034 cites W2130375190 @default.
- W1572608034 cites W2135063623 @default.
- W1572608034 cites W2135942966 @default.
- W1572608034 cites W2139395239 @default.
- W1572608034 cites W2143701145 @default.
- W1572608034 cites W2151266799 @default.
- W1572608034 cites W2152472678 @default.
- W1572608034 cites W2401361688 @default.
- W1572608034 cites W2922915278 @default.
- W1572608034 cites W3049811 @default.
- W1572608034 cites W39288719 @default.
- W1572608034 cites W4243218069 @default.
- W1572608034 cites W4285719527 @default.
- W1572608034 cites W4297810568 @default.
- W1572608034 doi "https://doi.org/10.1007/s40268-015-0092-x" @default.
- W1572608034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4488186" @default.
- W1572608034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25943458" @default.
- W1572608034 hasPublicationYear "2015" @default.
- W1572608034 type Work @default.
- W1572608034 sameAs 1572608034 @default.
- W1572608034 citedByCount "100" @default.
- W1572608034 countsByYear W15726080342015 @default.
- W1572608034 countsByYear W15726080342016 @default.
- W1572608034 countsByYear W15726080342017 @default.
- W1572608034 countsByYear W15726080342018 @default.
- W1572608034 countsByYear W15726080342019 @default.
- W1572608034 countsByYear W15726080342020 @default.
- W1572608034 countsByYear W15726080342021 @default.
- W1572608034 countsByYear W15726080342022 @default.
- W1572608034 countsByYear W15726080342023 @default.
- W1572608034 crossrefType "journal-article" @default.
- W1572608034 hasAuthorship W1572608034A5085591276 @default.
- W1572608034 hasBestOaLocation W15726080341 @default.
- W1572608034 hasConcept C118552586 @default.
- W1572608034 hasConcept C15744967 @default.
- W1572608034 hasConcept C169760540 @default.
- W1572608034 hasConcept C185592680 @default.
- W1572608034 hasConcept C2776412080 @default.
- W1572608034 hasConcept C2776921671 @default.
- W1572608034 hasConcept C2777126507 @default.
- W1572608034 hasConcept C2780057945 @default.