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• W1572733237 startingPage "85" @default.
• W1572733237 abstract "Coal tar is a significant product generated from coal pyrolysis. Coal tar can be utilized as raw materials for various industries. It is also a type of raw material from which phenols, naphthalenes, and anthracene can be extracted. The present study was designed to investigate the possibility of coal tar creosote to induce oxidative stress and biochemical perturbations in rat liver and the role of rosemary (Rosmarinus officinalis) in ameliorating its toxic effects. Male Wister Albino rats were randomly divided into four groups of seven each, group I served as control; group II treated with rosemary (10 mL of water extract/kg BW for 21 days), group III received coal tar creosote (200 mg/4 mL olive oil/kg BW for 3 days), and group IV treated with both rosemary and coal tar creosote. The administration of coal tar creosote significantly caused elevation in lipid peroxidation (LPO) and reduction in the activities of glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST). A significant decrease in reduced glutathione (GSH) content was also observed. Liver aminotransferases aspartate transaminase (AST) and alanine transaminase (ALT)] and alkaline phosphatase (AlP) were significantly decreased while lactate dehydrogenase (LDH) was increased. Rosemary pretreatment to coal tar creosote-treated rats decreased LPO level and normalized GPx, GR, SOD, CAT, and GST activities, while GSH content was increased. Also, liver AST, ALT, AlP, and LDH were maintained near normal level due to rosemary treatment. In conclusion, rosemary has beneficial effects and could be able to antagonize coal tar creosote toxicity." @default.
• W1572733237 created "2016-06-24" @default.
• W1572733237 creator A5049733920 @default.
• W1572733237 creator A5081129054 @default.
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• W1572733237 date "2014-07-09" @default.
• W1572733237 modified "2023-10-05" @default.
• W1572733237 title "Oxidative stress modulation by<i>R</i><i>osmarinus officinalis</i>in creosote-induced hepatotoxicity" @default.
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• W1572733237 doi "https://doi.org/10.1002/tox.22024" @default.
• W1572733237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25044495" @default.
• W1572733237 hasPublicationYear "2014" @default.
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