FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572743239> ?p ?o ?g. }

• W1572743239 endingPage "587" @default.
• W1572743239 startingPage "579" @default.
• W1572743239 abstract "Hyperinsulinaemia and insulin resistance usually precede clinical hyperglycaemia and Type 2 diabetes. Thus, plasma insulin concentrations and insulin resistance are important quantitative traits associated with risk of Type 2 diabetes, and represent key measures for genetic analysis of the syndrome. We carried out a genome-wide search for loci related to plasma insulin concentrations and insulin resistance in 330 extended, community-based pedigrees from the Framingham Heart Study. Normalized deviates of the standardized residuals of plasma insulin concentrations in the fasting state, 2 h after oral glucose challenge and as a measure of insulin resistance were used in linkage analysis with the variance components model implemented in the computer program SOLAR. The results suggest susceptibility loci influencing plasma concentrations of fasting insulin and insulin resistance on chromosomes 11 (LOD 2.43 at 85 cM close to D11S2002) and 17 (LOD 1.8 at 60 cM, close to D17S784); and susceptibility loci influencing 2-h plasma insulin concentrations on chromosomes 9 (LOD 2.8 at 80 cM, close to D9S922) and 19 (LOD 1.8 at 66 cM, close to D19S245). The results of the analysis of 1000 simulations of the trait and an unlinked marker suggest that in a genome scan of 401 markers fewer than one LOD score over 1 would be due to Type 1 error, and be a false positive. We conclude that these suggestive regions for quantitative pre-diabetic insulin traits could contain major loci in the pathogenesis of Type 2 diabetes." @default.
• W1572743239 created "2016-06-24" @default.
• W1572743239 creator A5000345809 @default.
• W1572743239 creator A5000776451 @default.
• W1572743239 creator A5029296269 @default.
• W1572743239 creator A5035126983 @default.
• W1572743239 creator A5043771784 @default.
• W1572743239 creator A5059560495 @default.
• W1572743239 date "2003-03-21" @default.
• W1572743239 modified "2023-10-18" @default.
• W1572743239 title "A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study" @default.
• W1572743239 cites W1542836032 @default.
• W1572743239 cites W1674786313 @default.
• W1572743239 cites W1675830194 @default.
• W1572743239 cites W1920052608 @default.
• W1572743239 cites W1970375804 @default.
• W1572743239 cites W1976741643 @default.
• W1572743239 cites W1976746636 @default.
• W1572743239 cites W1999449727 @default.
• W1572743239 cites W2002896174 @default.
• W1572743239 cites W2004507897 @default.
• W1572743239 cites W2010760524 @default.
• W1572743239 cites W2017135440 @default.
• W1572743239 cites W2018135697 @default.
• W1572743239 cites W2028285640 @default.
• W1572743239 cites W2038686627 @default.
• W1572743239 cites W2041911313 @default.
• W1572743239 cites W2046519484 @default.
• W1572743239 cites W2048667936 @default.
• W1572743239 cites W2056319298 @default.
• W1572743239 cites W2085236608 @default.
• W1572743239 cites W2085493246 @default.
• W1572743239 cites W2085760982 @default.
• W1572743239 cites W2088720134 @default.
• W1572743239 cites W2104310970 @default.
• W1572743239 cites W2118267307 @default.
• W1572743239 cites W2120688902 @default.
• W1572743239 cites W2129316761 @default.
• W1572743239 cites W2132012888 @default.
• W1572743239 cites W2143554720 @default.
• W1572743239 cites W2144446479 @default.
• W1572743239 cites W2146845495 @default.
• W1572743239 cites W2148959338 @default.
• W1572743239 cites W2149158598 @default.
• W1572743239 cites W2159829835 @default.
• W1572743239 cites W2160234571 @default.
• W1572743239 cites W2162596964 @default.
• W1572743239 cites W2211287272 @default.
• W1572743239 cites W2319176243 @default.
• W1572743239 cites W23760921 @default.
• W1572743239 cites W2607031541 @default.
• W1572743239 cites W2917598312 @default.
• W1572743239 cites W4233562854 @default.
• W1572743239 cites W91106440 @default.
• W1572743239 doi "https://doi.org/10.1007/s00125-003-1066-z" @default.
• W1572743239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12739029" @default.
• W1572743239 hasPublicationYear "2003" @default.
• W1572743239 type Work @default.
• W1572743239 sameAs 1572743239 @default.
• W1572743239 citedByCount "47" @default.
• W1572743239 countsByYear W15727432392012 @default.
• W1572743239 countsByYear W15727432392013 @default.
• W1572743239 countsByYear W15727432392014 @default.
• W1572743239 countsByYear W15727432392022 @default.
• W1572743239 crossrefType "journal-article" @default.
• W1572743239 hasAuthorship W1572743239A5000345809 @default.
• W1572743239 hasAuthorship W1572743239A5000776451 @default.
• W1572743239 hasAuthorship W1572743239A5029296269 @default.
• W1572743239 hasAuthorship W1572743239A5035126983 @default.
• W1572743239 hasAuthorship W1572743239A5043771784 @default.
• W1572743239 hasAuthorship W1572743239A5059560495 @default.
• W1572743239 hasBestOaLocation W15727432391 @default.
• W1572743239 hasConcept C104317684 @default.
• W1572743239 hasConcept C111815664 @default.
• W1572743239 hasConcept C112672928 @default.
• W1572743239 hasConcept C11783203 @default.
• W1572743239 hasConcept C126322002 @default.
• W1572743239 hasConcept C134018914 @default.
• W1572743239 hasConcept C2777180221 @default.
• W1572743239 hasConcept C2777391703 @default.
• W1572743239 hasConcept C2779134260 @default.
• W1572743239 hasConcept C2779234561 @default.
• W1572743239 hasConcept C2779306644 @default.
• W1572743239 hasConcept C54355233 @default.
• W1572743239 hasConcept C555293320 @default.
• W1572743239 hasConcept C71924100 @default.
• W1572743239 hasConcept C81941488 @default.
• W1572743239 hasConcept C86803240 @default.
• W1572743239 hasConceptScore W1572743239C104317684 @default.
• W1572743239 hasConceptScore W1572743239C111815664 @default.
• W1572743239 hasConceptScore W1572743239C112672928 @default.
• W1572743239 hasConceptScore W1572743239C11783203 @default.
• W1572743239 hasConceptScore W1572743239C126322002 @default.
• W1572743239 hasConceptScore W1572743239C134018914 @default.
• W1572743239 hasConceptScore W1572743239C2777180221 @default.
• W1572743239 hasConceptScore W1572743239C2777391703 @default.
• W1572743239 hasConceptScore W1572743239C2779134260 @default.
• W1572743239 hasConceptScore W1572743239C2779234561 @default.

• next