FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572803603> ?p ?o ?g. }

• W1572803603 endingPage "70" @default.
• W1572803603 startingPage "1365" @default.
• W1572803603 abstract "Recent studies demonstrated that the resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) could be reversed by various chemotherapeutic agents. In the present study, we investigated the role of Akt in the apoptosis resistance to TRAIL and chemotherapeutic agents-induced TRAIL sensitization in human renal cell carcinoma cells. Apoptosis assays and Western blot analyses revealed that apoptosis resistance to TRAIL correlates well with the level of Akt phosphorylation at Ser 473 rather than protein expression levels of TRAIL receptors, DR4 and DR5. The apoptosis sensitivity to TRAIL in TRAIL-resistant SKRC-49 and TRAIL-sensitive Caki-1 cells was altered by modulation of Akt activity, which increased the protein expression of cellular FADD-like IL-1beta-converting enzyme-like inhibitory protein (cFLIP). Paclitaxel (5 and 100 nM) and cisplatin (10 microM) but not etoposide (1 and 10 microM) promoted TRAIL-induced apoptosis in SKRC-49 cells, which was not mediated by increased TRAIL receptor expression but by chemotherapeutic agents-induced Akt inactivation through ceramide formation derived from sphingomyelin hydrolysis. Of note, the low concentration (5 nM) of paclitaxel promoted ceramide formation and TRAIL-induced apoptosis predominantly in SKRC-49 cells but not in the normal renal proximal tubular epithelial cells. Our results may provide a novel therapeutic modality for selective killing of renal cell carcinoma with minimal toxicity on normal renal cells." @default.
• W1572803603 created "2016-06-24" @default.
• W1572803603 creator A5038413661 @default.
• W1572803603 creator A5041864509 @default.
• W1572803603 creator A5053992798 @default.
• W1572803603 creator A5070709503 @default.
• W1572803603 date "2003-03-15" @default.
• W1572803603 modified "2023-09-23" @default.
• W1572803603 title "Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel." @default.
• W1572803603 cites W1484817497 @default.
• W1572803603 cites W1494294895 @default.
• W1572803603 cites W1514054607 @default.
• W1572803603 cites W1519516598 @default.
• W1572803603 cites W1568060924 @default.
• W1572803603 cites W1633622810 @default.
• W1572803603 cites W1769366348 @default.
• W1572803603 cites W1770433837 @default.
• W1572803603 cites W1780868497 @default.
• W1572803603 cites W1797447800 @default.
• W1572803603 cites W1976033985 @default.
• W1572803603 cites W1985850927 @default.
• W1572803603 cites W2022791001 @default.
• W1572803603 cites W2024306318 @default.
• W1572803603 cites W2038253447 @default.
• W1572803603 cites W2044825593 @default.
• W1572803603 cites W2074860444 @default.
• W1572803603 cites W2085233944 @default.
• W1572803603 cites W2097767970 @default.
• W1572803603 cites W2100470338 @default.
• W1572803603 cites W2106284224 @default.
• W1572803603 cites W2109232632 @default.
• W1572803603 cites W2117290383 @default.
• W1572803603 cites W2125649123 @default.
• W1572803603 cites W2126959399 @default.
• W1572803603 cites W2132661761 @default.
• W1572803603 cites W2150287029 @default.
• W1572803603 cites W2151560330 @default.
• W1572803603 cites W2162360684 @default.
• W1572803603 cites W2172260980 @default.
• W1572803603 cites W2175632213 @default.
• W1572803603 cites W2325836085 @default.
• W1572803603 cites W2330709458 @default.
• W1572803603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12649200" @default.
• W1572803603 hasPublicationYear "2003" @default.
• W1572803603 type Work @default.
• W1572803603 sameAs 1572803603 @default.
• W1572803603 citedByCount "14" @default.
• W1572803603 countsByYear W15728036032012 @default.
• W1572803603 countsByYear W15728036032015 @default.
• W1572803603 countsByYear W15728036032018 @default.
• W1572803603 countsByYear W15728036032022 @default.
• W1572803603 crossrefType "journal-article" @default.
• W1572803603 hasAuthorship W1572803603A5038413661 @default.
• W1572803603 hasAuthorship W1572803603A5041864509 @default.
• W1572803603 hasAuthorship W1572803603A5053992798 @default.
• W1572803603 hasAuthorship W1572803603A5070709503 @default.
• W1572803603 hasConcept C121608353 @default.
• W1572803603 hasConcept C126322002 @default.
• W1572803603 hasConcept C17991360 @default.
• W1572803603 hasConcept C185592680 @default.
• W1572803603 hasConcept C190283241 @default.
• W1572803603 hasConcept C203014093 @default.
• W1572803603 hasConcept C2776055636 @default.
• W1572803603 hasConcept C2777851122 @default.
• W1572803603 hasConcept C31573885 @default.
• W1572803603 hasConcept C502942594 @default.
• W1572803603 hasConcept C55493867 @default.
• W1572803603 hasConcept C71924100 @default.
• W1572803603 hasConcept C75217442 @default.
• W1572803603 hasConcept C86803240 @default.
• W1572803603 hasConcept C96232424 @default.
• W1572803603 hasConcept C98424977 @default.
• W1572803603 hasConceptScore W1572803603C121608353 @default.
• W1572803603 hasConceptScore W1572803603C126322002 @default.
• W1572803603 hasConceptScore W1572803603C17991360 @default.
• W1572803603 hasConceptScore W1572803603C185592680 @default.
• W1572803603 hasConceptScore W1572803603C190283241 @default.
• W1572803603 hasConceptScore W1572803603C203014093 @default.
• W1572803603 hasConceptScore W1572803603C2776055636 @default.
• W1572803603 hasConceptScore W1572803603C2777851122 @default.
• W1572803603 hasConceptScore W1572803603C31573885 @default.
• W1572803603 hasConceptScore W1572803603C502942594 @default.
• W1572803603 hasConceptScore W1572803603C55493867 @default.
• W1572803603 hasConceptScore W1572803603C71924100 @default.
• W1572803603 hasConceptScore W1572803603C75217442 @default.
• W1572803603 hasConceptScore W1572803603C86803240 @default.
• W1572803603 hasConceptScore W1572803603C96232424 @default.
• W1572803603 hasConceptScore W1572803603C98424977 @default.
• W1572803603 hasIssue "6" @default.
• W1572803603 hasLocation W15728036031 @default.
• W1572803603 hasOpenAccess W1572803603 @default.
• W1572803603 hasPrimaryLocation W15728036031 @default.
• W1572803603 hasRelatedWork W2130504042 @default.
• W1572803603 hasRelatedWork W2264596424 @default.
• W1572803603 hasRelatedWork W2359920467 @default.
• W1572803603 hasRelatedWork W2550432618 @default.
• W1572803603 hasRelatedWork W2790875452 @default.
• W1572803603 hasRelatedWork W2866093541 @default.

• next