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- W1572809404 abstract "Multiple targeted therapies have been shown to be effective for treating cancer such as imatinib for treating chronic myelogenous leukemia, erlotinib for non-small-cell lung cancers and trastuzumab for HER2 positive breast cancer. The sporadic sensitivity to these reagents has precipitated many inquiries into the relationship between phenotype and genotype. We have developed an in vitro cellular system to evaluate the relationship between tumor genotypes and cancer cell sensitivity over 240 human tumor cell lines. We used a panel of targeted therapeutics (such as erlotinib, CL-1040, and dasatinib) to demonstrate the prognostic value of this in vitro approach for developing anticancer drugs. This is a novel approach for a drug testing strategy for targeted anticancer therapeutics of interest to those in personalized medicine. This approach would help to match the drugs to a more efficacious patient population." @default.
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- W1572809404 date "2010-10-01" @default.
- W1572809404 modified "2023-10-12" @default.
- W1572809404 title "240 human tumor cell line profiling to evaluate relationships between tumor genotypes and cancer cell sensitivity" @default.
- W1572809404 doi "https://doi.org/10.1158/diag-10-a1" @default.
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