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- W1572853762 abstract "Knowing the need for new drugs against the etiologic agent of Chagas disease and considering the biological properties of naphthoquinones and isoxazoles, the effect of three isoxazolyl-naphthoquinones on the growth of Trypanosoma cruzi was studied. To evaluate the activity of the compounds on epimastigote forms, growth curves with different concentrations of 2-hydroxi-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-4 -imine (I), N-(3,4-dimethyl-5-isoxazolyl)-4-amino-1,2-naphthoquinone (II), 2-acetyl-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-imine (III) and Nifurtimox as reference drug were made. The studies on the trypomastigote form were performed on two month old BALB/c mice, evaluating parasitemia on day 13 post infection. The results obtained with epimastigotes showed that all drugs induced alterations in motility, morphology, viability and/or lysis of parasites. For the treatments on trypomastigotes the best results were obtained with (I) which reduced parasitemia compared to untreated controls." @default.
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- W1572853762 date "1990-10-01" @default.
- W1572853762 modified "2023-10-01" @default.
- W1572853762 title "Isoxazolylnaphthoquinone effects on the growth of Trypanosoma cruzi." @default.
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