FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1572942558> ?p ?o ?g. }

• W1572942558 endingPage "561" @default.
• W1572942558 startingPage "553" @default.
• W1572942558 abstract "We developed three novel positron‐emission tomography (PET) probes, 2‐ tert ‐butyl‐4‐chloro‐5‐{6‐[2‐(2[ 18 F]fluoroethoxy)‐ethoxy]‐pyridin‐3‐ylmethoxy}‐2H‐pyridazin‐3‐one ([ 18 F]BCPP‐EF), 2‐ tert ‐butyl‐4‐chloro‐5‐[6‐(4‐[ 18 F]fluorobutoxy)‐pyridin‐3‐ylmethoxy]‐2H‐pyridazin‐3‐one ([ 18 F]BCPP‐BF), and 2‐ tert ‐butyl‐4‐chloro‐5‐{6‐[2‐(2‐[ 11 C]methoxy‐ethoxy)‐ethoxy]‐pyridin‐3‐ylmethoxy}‐2H‐pyridazin‐3‐one ([ 11 C]BCPP‐EM), for quantitative imaging of mitochondrial complex 1 (MC‐1) activity in vivo . These three PET probes were successfully labeled by nucleophilic [ 18 F]fluorination or by [ 11 C]methylation of their corresponding precursor with sufficient radioactivity yield, good radiochemical purity, and sufficiently high specific radioactivity for PET measurement. The specificity of these probes for binding to MC‐1 was assessed with rotenone, a specific MC‐1 inhibitor, by a rat brain slice imaging method in vitro . Rat whole‐body imaging by small‐animal PET demonstrated that all probes showed high uptake levels in the brain as well as in the heart sufficient to image them clearly. The rank order of uptake levels in the brain and the heart just after injection was as follows: high in [ 18 F]BCPP‐BF, intermediate in [ 11 C]BCPP‐EM, and low in [ 18 F]BCPP‐EF. The kinetics of [ 18 F]BCPP‐EF and [ 11 C]BCPP‐EM provided a reversible binding pattern, whereas [ 18 F]BCPP‐BF showed nonreversible accumulation‐type kinetics in the brain and heart. Metabolite analyses indicated that these three compounds were rapidly metabolized in the plasma but relatively stable in the rat brain up to 60 min post‐injection. The present study demonstrated that [ 18 F]BCPP‐EF could be a useful PET probe for quantitative imaging of MC‐1 activity in the living brain by PET." @default.
• W1572942558 created "2016-06-24" @default.
• W1572942558 creator A5016382989 @default.
• W1572942558 creator A5038010166 @default.
• W1572942558 creator A5054074865 @default.
• W1572942558 creator A5070077485 @default.
• W1572942558 date "2013-07-30" @default.
• W1572942558 modified "2023-10-10" @default.
• W1572942558 title "Development of novel PET probes, [¹⁸F]BCPP-EF, [¹⁸F]BCPP-BF, and [¹¹C]BCPP-EM for mitochondrial complex 1 imaging in the living brain" @default.
• W1572942558 cites W1963685102 @default.
• W1572942558 cites W1977854822 @default.
• W1572942558 cites W1985277575 @default.
• W1572942558 cites W2028370563 @default.
• W1572942558 cites W2031021360 @default.
• W1572942558 cites W2037121432 @default.
• W1572942558 cites W2050357506 @default.
• W1572942558 cites W2064865731 @default.
• W1572942558 cites W2076088762 @default.
• W1572942558 cites W2102792189 @default.
• W1572942558 cites W2108931227 @default.
• W1572942558 cites W2166648722 @default.
• W1572942558 doi "https://doi.org/10.1002/jlcr.3056" @default.
• W1572942558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24285187" @default.
• W1572942558 hasPublicationYear "2013" @default.
• W1572942558 type Work @default.
• W1572942558 sameAs 1572942558 @default.
• W1572942558 citedByCount "46" @default.
• W1572942558 countsByYear W15729425582013 @default.
• W1572942558 countsByYear W15729425582014 @default.
• W1572942558 countsByYear W15729425582015 @default.
• W1572942558 countsByYear W15729425582016 @default.
• W1572942558 countsByYear W15729425582017 @default.
• W1572942558 countsByYear W15729425582018 @default.
• W1572942558 countsByYear W15729425582019 @default.
• W1572942558 countsByYear W15729425582020 @default.
• W1572942558 countsByYear W15729425582021 @default.
• W1572942558 countsByYear W15729425582022 @default.
• W1572942558 countsByYear W15729425582023 @default.
• W1572942558 crossrefType "journal-article" @default.
• W1572942558 hasAuthorship W1572942558A5016382989 @default.
• W1572942558 hasAuthorship W1572942558A5038010166 @default.
• W1572942558 hasAuthorship W1572942558A5054074865 @default.
• W1572942558 hasAuthorship W1572942558A5070077485 @default.
• W1572942558 hasConcept C150903083 @default.
• W1572942558 hasConcept C185592680 @default.
• W1572942558 hasConcept C207001950 @default.
• W1572942558 hasConcept C86803240 @default.
• W1572942558 hasConceptScore W1572942558C150903083 @default.
• W1572942558 hasConceptScore W1572942558C185592680 @default.
• W1572942558 hasConceptScore W1572942558C207001950 @default.
• W1572942558 hasConceptScore W1572942558C86803240 @default.
• W1572942558 hasIssue "11" @default.
• W1572942558 hasLocation W15729425581 @default.
• W1572942558 hasLocation W15729425582 @default.
• W1572942558 hasOpenAccess W1572942558 @default.
• W1572942558 hasPrimaryLocation W15729425581 @default.
• W1572942558 hasRelatedWork W1531601525 @default.
• W1572942558 hasRelatedWork W2319480705 @default.
• W1572942558 hasRelatedWork W2384464875 @default.
• W1572942558 hasRelatedWork W2398689458 @default.
• W1572942558 hasRelatedWork W2606230654 @default.
• W1572942558 hasRelatedWork W2607424097 @default.
• W1572942558 hasRelatedWork W2748952813 @default.
• W1572942558 hasRelatedWork W2899084033 @default.
• W1572942558 hasRelatedWork W2948807893 @default.
• W1572942558 hasRelatedWork W2778153218 @default.
• W1572942558 hasVolume "56" @default.
• W1572942558 isParatext "false" @default.
• W1572942558 isRetracted "false" @default.
• W1572942558 magId "1572942558" @default.
• W1572942558 workType "article" @default.