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- W1573031330 abstract "Rather than obliterating the need for histopathologic examination, the availability of modern imaging modalities and efficient antitumor therapies heighten the importance of timely and accurate histologic diagnosis of hepatocellular carcinoma (HCC). More than ever before, there is now real hope of curative intervention for HCC discovered in an early stage. Thus, a key diagnostic role is assigned to histopathology whenever radiologic findings are inconclusive. While classical micromorphologic (cytologic and architectural) features are still at the heart of histopathologic evaluation, there is ongoing effort to complement histologic findings with the analysis of characteristic immunohistochemical (IHC) markers. In all modern pathology centers, IHC has become a cornerstone of the diagnostic process. The aid provided by immunomarkers is particularly resorted to when ambiguous cases are encountered. This review focuses on the role of IHC in one of the major differential diagnostic dilemmas related to HCC: the benign versus malignant problem. The question of malignant character may arise either when evaluating biopsies of suspicious nodules obtained from high-risk patients, or when analyzing tissue from hepatocellular tumors discovered in a non-cirrhotic background. Accordingly, the review will separately discuss the problem of small nodular lesions in cirrhosis, and the issue of large tumors arising in the normal liver. In our attempt to summarize state-of-the-art expert opinion, we have largely built on two outstanding reviews (Park, 2011; Roncalli et al., 2011), and tried to provide an update on recent progress made in the field." @default.
- W1573031330 created "2016-06-24" @default.
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- W1573031330 date "2012-03-02" @default.
- W1573031330 modified "2023-10-02" @default.
- W1573031330 title "Recent Advances in the Immunohistochemistry- Aided Differential Diagnosis of Benign Versus Malignant Hepatocellular Lesions" @default.
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- W1573031330 doi "https://doi.org/10.5772/27211" @default.
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