Matches in SemOpenAlex for { <https://semopenalex.org/work/W1573089314> ?p ?o ?g. }
- W1573089314 endingPage "510" @default.
- W1573089314 startingPage "495" @default.
- W1573089314 abstract "Understanding the regulation of islet cell mass has important implications for the discovery of regenerative therapies for diabetes. The liver plays a central role in metabolism and the regulation of endocrine cell number, but liver-derived factors that regulate α-cell and β-cell mass remain unidentified. We propose a nutrient-sensing circuit between liver and pancreas in which glucagon-dependent control of hepatic amino acid metabolism regulates α-cell mass. We found that glucagon receptor inhibition reduced hepatic amino acid catabolism, increased serum amino acids, and induced α-cell proliferation in an mTOR-dependent manner. In addition, mTOR inhibition blocked amino-acid-dependent α-cell replication ex vivo and enabled conversion of α-cells into β-like cells in vivo. Serum amino acids and α-cell proliferation were increased in neonatal mice but fell throughout postnatal development in a glucagon-dependent manner. These data reveal that amino acids act as sensors of glucagon signaling and can function as growth factors that increase α-cell proliferation." @default.
- W1573089314 created "2016-06-24" @default.
- W1573089314 creator A5015628950 @default.
- W1573089314 creator A5017437319 @default.
- W1573089314 creator A5017656603 @default.
- W1573089314 creator A5028349586 @default.
- W1573089314 creator A5028575353 @default.
- W1573089314 creator A5041030415 @default.
- W1573089314 creator A5041383806 @default.
- W1573089314 creator A5042306092 @default.
- W1573089314 creator A5044115817 @default.
- W1573089314 creator A5047503534 @default.
- W1573089314 creator A5050134822 @default.
- W1573089314 creator A5059751258 @default.
- W1573089314 creator A5059962014 @default.
- W1573089314 creator A5072858878 @default.
- W1573089314 creator A5075992843 @default.
- W1573089314 creator A5076853295 @default.
- W1573089314 creator A5087349635 @default.
- W1573089314 date "2015-07-01" @default.
- W1573089314 modified "2023-10-18" @default.
- W1573089314 title "Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass" @default.
- W1573089314 cites W1598254642 @default.
- W1573089314 cites W1976896999 @default.
- W1573089314 cites W1983705094 @default.
- W1573089314 cites W2003946536 @default.
- W1573089314 cites W2005250386 @default.
- W1573089314 cites W2008227148 @default.
- W1573089314 cites W2022382384 @default.
- W1573089314 cites W2026748222 @default.
- W1573089314 cites W2030368058 @default.
- W1573089314 cites W2033228549 @default.
- W1573089314 cites W2045325331 @default.
- W1573089314 cites W2051522090 @default.
- W1573089314 cites W2057361172 @default.
- W1573089314 cites W2059576139 @default.
- W1573089314 cites W2067387842 @default.
- W1573089314 cites W2076794464 @default.
- W1573089314 cites W2095995901 @default.
- W1573089314 cites W2101199896 @default.
- W1573089314 cites W2103391067 @default.
- W1573089314 cites W2109163588 @default.
- W1573089314 cites W2112871433 @default.
- W1573089314 cites W2113278846 @default.
- W1573089314 cites W2127063807 @default.
- W1573089314 cites W2127167047 @default.
- W1573089314 cites W2127457915 @default.
- W1573089314 cites W2129585918 @default.
- W1573089314 cites W2137505472 @default.
- W1573089314 cites W2145833822 @default.
- W1573089314 cites W2148078342 @default.
- W1573089314 cites W2148653634 @default.
- W1573089314 cites W2149343591 @default.
- W1573089314 cites W2155460927 @default.
- W1573089314 cites W2156888164 @default.
- W1573089314 cites W2157587269 @default.
- W1573089314 cites W2169903226 @default.
- W1573089314 cites W2323566388 @default.
- W1573089314 cites W97648961 @default.
- W1573089314 doi "https://doi.org/10.1016/j.celrep.2015.06.034" @default.
- W1573089314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26166562" @default.
- W1573089314 hasPublicationYear "2015" @default.
- W1573089314 type Work @default.
- W1573089314 sameAs 1573089314 @default.
- W1573089314 citedByCount "141" @default.
- W1573089314 countsByYear W15730893142015 @default.
- W1573089314 countsByYear W15730893142016 @default.
- W1573089314 countsByYear W15730893142017 @default.
- W1573089314 countsByYear W15730893142018 @default.
- W1573089314 countsByYear W15730893142019 @default.
- W1573089314 countsByYear W15730893142020 @default.
- W1573089314 countsByYear W15730893142021 @default.
- W1573089314 countsByYear W15730893142022 @default.
- W1573089314 countsByYear W15730893142023 @default.
- W1573089314 crossrefType "journal-article" @default.
- W1573089314 hasAuthorship W1573089314A5015628950 @default.
- W1573089314 hasAuthorship W1573089314A5017437319 @default.
- W1573089314 hasAuthorship W1573089314A5017656603 @default.
- W1573089314 hasAuthorship W1573089314A5028349586 @default.
- W1573089314 hasAuthorship W1573089314A5028575353 @default.
- W1573089314 hasAuthorship W1573089314A5041030415 @default.
- W1573089314 hasAuthorship W1573089314A5041383806 @default.
- W1573089314 hasAuthorship W1573089314A5042306092 @default.
- W1573089314 hasAuthorship W1573089314A5044115817 @default.
- W1573089314 hasAuthorship W1573089314A5047503534 @default.
- W1573089314 hasAuthorship W1573089314A5050134822 @default.
- W1573089314 hasAuthorship W1573089314A5059751258 @default.
- W1573089314 hasAuthorship W1573089314A5059962014 @default.
- W1573089314 hasAuthorship W1573089314A5072858878 @default.
- W1573089314 hasAuthorship W1573089314A5075992843 @default.
- W1573089314 hasAuthorship W1573089314A5076853295 @default.
- W1573089314 hasAuthorship W1573089314A5087349635 @default.
- W1573089314 hasBestOaLocation W15730893141 @default.
- W1573089314 hasConcept C103395026 @default.
- W1573089314 hasConcept C126322002 @default.
- W1573089314 hasConcept C134018914 @default.
- W1573089314 hasConcept C1491633281 @default.
- W1573089314 hasConcept C165220095 @default.