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- W157325334 abstract "Since the demonstration in 1941 by Huggins and Hodges on the endocrine dependency of neoplastic human prostate [1], this relationship has formed the foundation for investigations into the mechanism(s) of steroid hormone action on hormone-responsive target tissues. The discovery of the high affinity and limited capacity of estrogen receptors in immature rat uterus by Jensen [2] has firmly established the initial steps of steroid hormone and target tissue interactions. The rigid structural requirements of steroid hormones, their specific binding to cytoplasmic receptor proteins to form receptor protein complexes, and their ability to elicit specific biological responses have been documented at molecular [3, 4], genetic [5, 6], and developmental [7, 8] levels. Similar receptor proteins for androgens [9, 10], estrogens [11, 12], and/or progestins [13] have been demonstrated to exist in the prostate gland of virtually all species studied." @default.
- W157325334 created "2016-06-24" @default.
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- W157325334 date "1984-01-01" @default.
- W157325334 modified "2023-09-27" @default.
- W157325334 title "Role of Androgen Receptors in Stromal-Epithelial Interactions in Prostatic Cancer" @default.
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- W157325334 doi "https://doi.org/10.1007/978-1-4613-2843-8_2" @default.
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