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• W1573672004 abstract "Brain derived neurotrophic factor is a neurotrophin of vital importance forneuron survival.It may therefore be of great help to people affected by sensorineuralhearing loss and cochlear implant users, as it has already beendemonstrated that it maintains neuronal cells alive and this proved to benecessary for the device to work.The issue with its clinical application is related to its large size that makesit difficult to deliver.In this thesis I took on one of the tasks of a European project.The objective of the Nanoear project is the creation of multifunctionalnanoparticles that could be used as drug carriers for a target delivery in theinner ear.The final aim is to find a substitute for BDNF protein, able to mimic itsaction but small enough to be attached to the nanoparticles and carry themto their target in the inner ear.The best method to obtain small peptides with these features is the phagedisplay. This technique allows selection of a pool of specific peptidesbinding specifically to an immobilized target.In collaboration with an English company involved in the project as well,we worked to set all the parameters in order to make the phage display forthis project feasible.As our goal was attaining BDNF mimetic peptides our target had to be itsfunctional receptor, TrkB.Starting from a polyA+ RNA library from adult human brain we could getthe genes coding for TrkB and BDNF and follow all the process up to theexpression of the two proteins in bacteria and in eukaryotic cells, as well.In order to include into nanoparticles the most specific peptides manyapproaches for the phage display were taken into consideration andexperimented on.This technique was in fact performed in vivo on guinea pigs and all theparameters were set for different trials in vitro either on eukaryotic cells oron the specific binding domain purified from bacteria.Therefore the results and the data obtained in this study can lead to a newgeneration of drug with great clinical potential." @default.
• W1573672004 created "2016-06-24" @default.
• W1573672004 creator A5056673324 @default.
• W1573672004 date "2008-01-01" @default.
• W1573672004 modified "2023-09-23" @default.
• W1573672004 title "Nanotechnologies and phage display: selection of peptides mimicking BDNF" @default.
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