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• W1573737370 abstract "Abstract Objectives In the present study, we aimed to examine whether fractions from an edible sea weed, Hizikia fusiformis, had immunomodulatory effects, particularly an anti-atopic effect, by attenuating the expression of T cell-dependent cytokines using in-vitro and in-vivo animal atopic dermatitis-like models. Methods The anti-atopic activities were examined in in vitro, and a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis-like mouse model using quantitative real-time polymerase chain reaction, electrophoretic-mobility shift and histophathological analysis. Key findings Our results showed that the final fraction (F2′) of H. fusiformis contained a higher amount of butanoic acid which was not found in the other fractions, and effectively inhibited T cell activation by inhibiting dephosphorylation of nuclear factor of activated T cells in electrophoretic-mobility shift assay. As a consequence, helper T cell-dependent cytokines, such as interleukin-2, -4 and interferon-γ, were significantly inhibited while activated with an anti-CD3 antibody. We also showed that skin challenged with DNCB successfully recovered when treated with 2.5 mg/kg, comparable to that by 0.25% prednicarbate. These results indicate that F2′ may contribute to inhibit T cell activation by eliminating Th cell-dependent cytokines. Conclusions Taken together, we concluded that F2′ containing butanoic acid may be a new functional anti-atopic candidate, which probably acts through nuclear factor of activated T cell inactivation mechanisms." @default.
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• W1573737370 date "2013-12-10" @default.
• W1573737370 modified "2023-10-16" @default.
• W1573737370 title "Hizikia fusiformis fractions successfully improve atopic dermatitis indices in anti-CD3-stimulated splenocytes and 2,4-dinitrochlorobenzene-treated BALB/c mice" @default.
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• W1573737370 doi "https://doi.org/10.1111/jphp.12179" @default.
• W1573737370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24354475" @default.
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