FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1573773354> ?p ?o ?g. }

• W1573773354 abstract "Management of acute respiratory distress syndrome (ARDS) in the intensive care unit (ICU) is clinically challenging and costly. Neuromuscular blocking agents may facilitate mechanical ventilation and improve oxygenation, but may result in prolonged recovery of neuromuscular function and acute quadriplegic myopathy syndrome (AQMS). The goal of this study was to address a hypothetical question via computer modeling: Would a reduction in intubation time of 6 hours and/or a reduction in the incidence of AQMS from 25% to 21%, provide enough benefit to justify a drug with an additional expenditure of $267 (the difference in acquisition cost between a generic and brand name neuromuscular blocker)?The base case was a 55 year-old man in the ICU with ARDS who receives neuromuscular blockade for 3.5 days. A Markov model was designed with hypothetical patients in 1 of 6 mutually exclusive health states: ICU-intubated, ICU-extubated, hospital ward, long-term care, home, or death, over a period of 6 months. The net monetary benefit was computed.Our computer simulation modeling predicted the mean cost for ARDS patients receiving standard care for 6 months to be $62,238 (5%-95% percentiles $42,259-$83,766), with an overall 6-month mortality of 39%. Assuming a ceiling ratio of $35,000, even if a drug (that cost $267 more) hypothetically reduced AQMS from 25% to 21% and decreased intubation time by 6 hours, the net monetary benefit would only equal $137.ARDS patients receiving a neuromuscular blocker have a high mortality, and unpredictable outcome, which results in large variability in costs per case. If a patient dies, there is no benefit to any drug that reduces ventilation time or AQMS incidence. A prospective, randomized pharmacoeconomic study of neuromuscular blockers in the ICU to asses AQMS or intubation times is impractical because of the highly variable clinical course of patients with ARDS." @default.
• W1573773354 created "2016-06-24" @default.
• W1573773354 creator A5015901694 @default.
• W1573773354 creator A5020229336 @default.
• W1573773354 creator A5023303080 @default.
• W1573773354 date "2006-03-15" @default.
• W1573773354 modified "2023-09-26" @default.
• W1573773354 title "A Markov computer simulation model of the economics of neuromuscular blockade in patients with acute respiratory distress syndrome" @default.
• W1573773354 cites W1482411635 @default.
• W1573773354 cites W1509398403 @default.
• W1573773354 cites W1597689181 @default.
• W1573773354 cites W1858789499 @default.
• W1573773354 cites W1969075912 @default.
• W1573773354 cites W1978960863 @default.
• W1573773354 cites W1980187445 @default.
• W1573773354 cites W1985040783 @default.
• W1573773354 cites W1987041486 @default.
• W1573773354 cites W1991937504 @default.
• W1573773354 cites W1993353641 @default.
• W1573773354 cites W1995504243 @default.
• W1573773354 cites W2000769608 @default.
• W1573773354 cites W2004441226 @default.
• W1573773354 cites W2016296643 @default.
• W1573773354 cites W2018866866 @default.
• W1573773354 cites W2019049609 @default.
• W1573773354 cites W2022728767 @default.
• W1573773354 cites W2038937027 @default.
• W1573773354 cites W2039655973 @default.
• W1573773354 cites W2043554639 @default.
• W1573773354 cites W2044151066 @default.
• W1573773354 cites W2045012616 @default.
• W1573773354 cites W2045215663 @default.
• W1573773354 cites W2046031893 @default.
• W1573773354 cites W2046518283 @default.
• W1573773354 cites W2050850707 @default.
• W1573773354 cites W2053627700 @default.
• W1573773354 cites W2054451736 @default.
• W1573773354 cites W2054479140 @default.
• W1573773354 cites W2055560107 @default.
• W1573773354 cites W2058372319 @default.
• W1573773354 cites W2064561545 @default.
• W1573773354 cites W2067940826 @default.
• W1573773354 cites W2071393615 @default.
• W1573773354 cites W2077680180 @default.
• W1573773354 cites W2077911309 @default.
• W1573773354 cites W2083931054 @default.
• W1573773354 cites W2094145886 @default.
• W1573773354 cites W2107294502 @default.
• W1573773354 cites W2113497441 @default.
• W1573773354 cites W2115308689 @default.
• W1573773354 cites W2115626471 @default.
• W1573773354 cites W2122863488 @default.
• W1573773354 cites W2130577637 @default.
• W1573773354 cites W2137292463 @default.
• W1573773354 cites W2143626238 @default.
• W1573773354 cites W2144049007 @default.
• W1573773354 cites W2151628967 @default.
• W1573773354 cites W2155900726 @default.
• W1573773354 cites W2161328469 @default.
• W1573773354 cites W2170010879 @default.
• W1573773354 cites W2170350031 @default.
• W1573773354 cites W2208931577 @default.
• W1573773354 cites W2337599582 @default.
• W1573773354 cites W2413138806 @default.
• W1573773354 cites W2473786944 @default.
• W1573773354 cites W3122426397 @default.
• W1573773354 cites W3203717762 @default.
• W1573773354 cites W4236747483 @default.
• W1573773354 cites W42413747 @default.
• W1573773354 cites W4245525675 @default.
• W1573773354 cites W4248053214 @default.
• W1573773354 cites W4249334197 @default.
• W1573773354 cites W69636228 @default.
• W1573773354 doi "https://doi.org/10.1186/1472-6947-6-15" @default.
• W1573773354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1431518" @default.
• W1573773354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16539706" @default.
• W1573773354 hasPublicationYear "2006" @default.
• W1573773354 type Work @default.
• W1573773354 sameAs 1573773354 @default.
• W1573773354 citedByCount "10" @default.
• W1573773354 countsByYear W15737733542012 @default.
• W1573773354 countsByYear W15737733542018 @default.
• W1573773354 countsByYear W15737733542022 @default.
• W1573773354 crossrefType "journal-article" @default.
• W1573773354 hasAuthorship W1573773354A5015901694 @default.
• W1573773354 hasAuthorship W1573773354A5020229336 @default.
• W1573773354 hasAuthorship W1573773354A5023303080 @default.
• W1573773354 hasBestOaLocation W15737733541 @default.
• W1573773354 hasConcept C126322002 @default.
• W1573773354 hasConcept C177713679 @default.
• W1573773354 hasConcept C194828623 @default.
• W1573773354 hasConcept C2776348555 @default.
• W1573773354 hasConcept C2777714996 @default.
• W1573773354 hasConcept C2778716859 @default.
• W1573773354 hasConcept C2909465803 @default.
• W1573773354 hasConcept C2910841738 @default.
• W1573773354 hasConcept C42219234 @default.
• W1573773354 hasConcept C71924100 @default.
• W1573773354 hasConceptScore W1573773354C126322002 @default.
• W1573773354 hasConceptScore W1573773354C177713679 @default.

• next