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- W1573815132 abstract "Publisher Summary This chapter discusses the interactions between drugs and gene products in Caenorhabditis elegans in genetic pharmacology. Caenorhabditis elegans has been a popular organism for the study of drug action. This chapter discusses the methods that used in compound-based studies of C. elegans and evaluates the effects of compounds on C. elegans growth, development, metabolism, and behavior. The strategies for the isolation, and analysis of drug-resistant and hypersensitive mutants are discussed. Studies combining bioactive compounds and C. elegans can be separated based on experimental strategy. The first strategy employs compounds with known modes of action to characterize particular aspects of C. elegans biology in wild type and mutant animals. The second strategy uses active compounds as screening or selective agents to isolate new drug-resistant or hypersensitive mutants and, thus, to identify genes with altered drug responses. Study of such compound-specific mutants can identify specific drug targets, and/or provide insight into the mechanism of drug action and the sites of drug action. The third strategy involves the use of C. elegans, both wild type and selected mutants, to analyze the mechanism of action of uncharacterized or poorly characterized compounds. This has led to the use of C. elegans as a primary screen for compounds active against parasitic nematodes." @default.
- W1573815132 created "2016-06-24" @default.
- W1573815132 creator A5042847234 @default.
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- W1573815132 date "1995-01-01" @default.
- W1573815132 modified "2023-09-24" @default.
- W1573815132 title "Chapter 8 Genetic Pharmacology: Interactions between Drugs and Gene Products in Caenorhabditis elegans" @default.
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- W1573815132 doi "https://doi.org/10.1016/s0091-679x(08)61388-6" @default.
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