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- W1573842929 abstract "Abstract It has been shown that Itk, a Tec kinase family member, is important for T cell development and differentiation. CD4+ and CD8+ T cells in Itk-/- mice display innate memory phenotype. Since Itk-/- CD8+ T cells preferentially develop into innate memory T cells in thymus, we aimed to determine whether naïve Itk-/- CD8+ T cells also preferentially differentiate into memory T cells after primary response to foreign antigens. To study the intrinsic and extrinsic effects of Itk in naïve CD8+ T cell differentiation into memory T cells, we used an OVA-Listeria monocytogenes infection model in which naïve OTI Rag1-/- T cells or OTI Itk-/- Rag1-/- T cells were adoptively transferred into Itk-/- or WT recipient mice. We found that naïve OTI ITK-/- Rag1-/- T cells have comparable ability to WT OTI Rag-/- T cells in memory T cell differentiation after a 5-week infection in WT hosts. In contrast, WT OTI Rag1-/- T cells are deficient in differentiating into memory T cells when placed in Itk-/- hosts. Although Itk affects the CD8+ T cell development in the thymus, its absence does not affect antigen specific CD8+ memory T cell differentiation. However, Itk-/- mice have an impaired environment for naïve CD8+ T cells differentiation into memory T cells during L. monocytogenes infection. These results suggest that Itk expression in cells other than CD8+ T cells is critical for supporting the antigen specific CD8+ T cell memory differentiation." @default.
- W1573842929 created "2016-06-24" @default.
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- W1573842929 date "2012-05-01" @default.
- W1573842929 modified "2023-10-16" @default.
- W1573842929 title "Itk and antigen specific CD8+ T cell memory differentiation (110.8)" @default.
- W1573842929 doi "https://doi.org/10.4049/jimmunol.188.supp.110.8" @default.
- W1573842929 hasPublicationYear "2012" @default.
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