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- W1573869152 abstract "Fc epsilon R-bearing lymphocytes were induced in vitro by the culture of peripheral lymphocytes from ragweed-sensitive patients with antigen E together with, or followed by, human IgE. Neither antigen E alone nor IgE alone induced Fc epsilon R(+) cells. As expected, culture of normal lymphocytes with the antigen and IgE failed to increase Fc epsilon R(+) cells. However, mixed lymphocyte cultures from two normal individuals responsed to human IgE for the induction of Fc epsilon R(+) cells. In both antigen-stimulated and mixed lymphocyte cultures, a portion of Fc epsilon R(+) cells induced in vitro were T lymphocytes. Evidence was obtained that Fc gamma R(+) cells are involved in the induction of Fc epsilon R(+) cells. Depletion of Fc gamma R(+) cells in the lymphocytes from ragweed-sensitive patients, before culture with antigen E and IgE, abolished the ability of the lymphocytes to respond to IgE for an increase in Fc epsilon R(+) cells." @default.
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- W1573869152 date "1980-02-01" @default.
- W1573869152 modified "2023-09-25" @default.
- W1573869152 title "Induction of Fc epsilon-receptor bearing cells in vitro in human peripheral lymphocytes." @default.
- W1573869152 doi "https://doi.org/10.4049/jimmunol.124.2.934" @default.
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