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• W1573896564 abstract "During oxidative stress, membrane lipids are one of the major targets of Reactive Oxygen Species (ROS) that are known to elicit oxidative decomposition of polyunsaturated fatty acids (PUFAs) of membrane phospholipids, a process usually referred to lipid peroxidation (Esterbauer et al., 1991). During this process, a number of carbonylic compounds are generated as final products, including acrolein, malondialdehyde (MDA) and 4hydroxyalkenals (Esterbauer et al., 1991). Among the 4-hydroxyalkenal class, 4hydroxynonenal (HNE) is the most abundant aldehyde produced (Dianzani et al., 1999). Over the years, HNE has achieved a status as one of the best recognized and most studied of the cytotoxic products of lipid peroxidation (Poli et al., 2008). In addition to studies on its bioactivity, HNE is commonly used as a biomarker for the occurrence and/or the extent of oxidative stress. It appears to be produced specifically by peroxidation of ω-6 PUFAs, such as linoleic acid, arachidonic acid (AA) and ┛-linolenic acid (Esterbauer et al., 1982). HNE has three main functional groups: the aldehyde group, the C=C double bond and the hydroxyl group, which can participate, alone or in sequence, in chemical reactions with other molecules (Esterbauer et al., 1991). HNE is a highly electrophilic molecule, which predisposes it to localize in the cell membranes. It can easily react with low molecular weight compounds, such as glutathione, with proteins, with lipids and, at higher concentration, with DNA (Esterbauer et al., 1991; Uchida, 2003). The double bond, the carbonyl group and the hydroxyl group, all contribute to making HNE highly reactive with nucleophiles with the primary reactivity of the molecule lying at the unsaturated bond of the C-3 atom. HNE has been shown to form Michael adducts via the C-3 atom with the sulfhydryl group of Cys residues, the imidazole group of His residues, and the e-amino group of Lys residues on a large number of proteins (Esterbauer et al., 1991). Recently, it has been proposed that HNE can also modify Arg residues of proteins (Isom et al., 2004). In addition to Michael adduct formation, Lys residues also form Schiff bases and pentylpyrrole adducts with HNE via the C-1 aldehyde group (Sayre et al., 1993; Petersen & Doorn, 2004; Schaur, 2003)" @default.
• W1573896564 created "2016-06-24" @default.
• W1573896564 creator A5032704680 @default.
• W1573896564 creator A5043387826 @default.
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• W1573896564 creator A5076485100 @default.
• W1573896564 creator A5087493522 @default.
• W1573896564 date "2012-02-10" @default.
• W1573896564 modified "2023-09-30" @default.
• W1573896564 title "Lipid Peroxidation in Colorectal Carcinogenesis: Bad and Good News" @default.
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