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• W1573967258 abstract "The γδ dendritic epidermal T cells (DETCs) can recognize stress-affected cells. Zal and colleagues show that at steady state, Vγ5 TCRs form immunological synapses that anchor DETC projections to the tight junctions of squamous keratinocytes. The surveillance of body barriers relies on resident T cells whose repertoires are biased toward particular γδ T cell antigen receptors (TCRs) according to location. These γδ TCRs can recognize ligands that emerge after stress. Through the use of intravital dynamics–immunosignal correlative microscopy, we found that γ-chain variable region 5 (Vγ5) TCRs expressed by epidermal T cells were constitutively clustered and functionally activated in vivo at steady state, forming true immunological synapses that polarized and anchored T cell projections at squamous keratinocyte tight junctions. This synaptogenesis depended on TCR variable domains, the kinase Lck and the integrin αEβ7 but not the γδ lineage or the receptor NKG2D. In response to tissue stress, TCR-proximal signals did not increase substantially but underwent stress mode–dependent relocalization toward the basal epidermis and Langerhans cells. Thus, the γδ TCR orchestrates barrier surveillance proactively, presumably by recognizing tissue ligands expressed in the steady state." @default.
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• W1573967258 date "2012-02-12" @default.
• W1573967258 modified "2023-10-06" @default.
• W1573967258 title "Body-barrier surveillance by epidermal γδ TCRs" @default.
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• W1573967258 doi "https://doi.org/10.1038/ni.2240" @default.
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