FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574006839> ?p ?o ?g. }

• W1574006839 endingPage "2178" @default.
• W1574006839 startingPage "2166" @default.
• W1574006839 abstract "Abstract The human mu‐opioid receptor gene (OPRM1) promoter contains a DNA sequence binding the repressor element 1 silencing transcription factor (REST) that is implicated in transcriptional repression. We investigated whether insulin‐like growth factor I (IGF‐I), which affects various aspects of neuronal induction and maturation, regulates OPRM1 transcription in neuronal cells in the context of the potential influence of REST. A series of OPRM1‐luciferase promoter/reporter constructs were transfected into two neuronal cell models, neuroblastoma‐derived SH‐SY5Y cells and PC12 cells. In the former, endogenous levels of human mu‐opioid receptor (hMOPr) mRNA were evaluated by real‐time PCR. IGF‐I up‐regulated OPRM1 transcription in: PC12 cells lacking REST, in SH‐SY5Y cells transfected with constructs deficient in the REST DNA binding element, or when REST was down‐regulated in retinoic acid‐differentiated cells. IGF‐I activates the signal transducer and activator of transcription‐3 signaling pathway and this transcription factor, binding to the signal transducer and activator of transcription‐1/3 DNA element located in the promoter, increases OPRM1 transcription. We propose that a reduction in REST is a critical switch enabling IGF‐I to up‐regulate hMOPr. These findings help clarify how hMOPr expression is regulated in neuronal cells." @default.
• W1574006839 created "2016-06-24" @default.
• W1574006839 creator A5013228218 @default.
• W1574006839 creator A5056093010 @default.
• W1574006839 creator A5071547436 @default.
• W1574006839 date "2008-02-18" @default.
• W1574006839 modified "2023-10-16" @default.
• W1574006839 title "Transcriptional activation of human mu-opioid receptor gene by insulin-like growth factor-I in neuronal cells is modulated by the transcription factor REST" @default.
• W1574006839 cites W1501580127 @default.
• W1574006839 cites W1516514579 @default.
• W1574006839 cites W1572325353 @default.
• W1574006839 cites W1600733651 @default.
• W1574006839 cites W1656220430 @default.
• W1574006839 cites W1886964562 @default.
• W1574006839 cites W1964679305 @default.
• W1574006839 cites W1967117492 @default.
• W1574006839 cites W1969021739 @default.
• W1574006839 cites W1973222840 @default.
• W1574006839 cites W1973527042 @default.
• W1574006839 cites W1974950833 @default.
• W1574006839 cites W1983241347 @default.
• W1574006839 cites W1988158039 @default.
• W1574006839 cites W1995207106 @default.
• W1574006839 cites W2000490360 @default.
• W1574006839 cites W2006918675 @default.
• W1574006839 cites W2012240654 @default.
• W1574006839 cites W2012405150 @default.
• W1574006839 cites W2012719507 @default.
• W1574006839 cites W2014311774 @default.
• W1574006839 cites W2022702828 @default.
• W1574006839 cites W2028199453 @default.
• W1574006839 cites W2033726443 @default.
• W1574006839 cites W2036453774 @default.
• W1574006839 cites W2041587083 @default.
• W1574006839 cites W2043813981 @default.
• W1574006839 cites W2045391586 @default.
• W1574006839 cites W2047453840 @default.
• W1574006839 cites W2048128132 @default.
• W1574006839 cites W2050006662 @default.
• W1574006839 cites W2056129202 @default.
• W1574006839 cites W2070812179 @default.
• W1574006839 cites W2077715854 @default.
• W1574006839 cites W2078733514 @default.
• W1574006839 cites W2078841246 @default.
• W1574006839 cites W2083019337 @default.
• W1574006839 cites W2087641892 @default.
• W1574006839 cites W2089210135 @default.
• W1574006839 cites W2091293786 @default.
• W1574006839 cites W2095314543 @default.
• W1574006839 cites W2100013751 @default.
• W1574006839 cites W2124486734 @default.
• W1574006839 cites W2126228551 @default.
• W1574006839 cites W2127238312 @default.
• W1574006839 cites W2138683224 @default.
• W1574006839 cites W2140872638 @default.
• W1574006839 cites W2147396082 @default.
• W1574006839 cites W2155546369 @default.
• W1574006839 cites W4205679763 @default.
• W1574006839 doi "https://doi.org/10.1111/j.1471-4159.2008.05303.x" @default.
• W1574006839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18284609" @default.
• W1574006839 hasPublicationYear "2008" @default.
• W1574006839 type Work @default.
• W1574006839 sameAs 1574006839 @default.
• W1574006839 citedByCount "26" @default.
• W1574006839 countsByYear W15740068392012 @default.
• W1574006839 countsByYear W15740068392014 @default.
• W1574006839 countsByYear W15740068392016 @default.
• W1574006839 countsByYear W15740068392017 @default.
• W1574006839 countsByYear W15740068392018 @default.
• W1574006839 countsByYear W15740068392020 @default.
• W1574006839 countsByYear W15740068392021 @default.
• W1574006839 countsByYear W15740068392022 @default.
• W1574006839 countsByYear W15740068392023 @default.
• W1574006839 crossrefType "journal-article" @default.
• W1574006839 hasAuthorship W1574006839A5013228218 @default.
• W1574006839 hasAuthorship W1574006839A5056093010 @default.
• W1574006839 hasAuthorship W1574006839A5071547436 @default.
• W1574006839 hasBestOaLocation W15740068391 @default.
• W1574006839 hasConcept C101762097 @default.
• W1574006839 hasConcept C104317684 @default.
• W1574006839 hasConcept C132376346 @default.
• W1574006839 hasConcept C138885662 @default.
• W1574006839 hasConcept C144825837 @default.
• W1574006839 hasConcept C150194340 @default.
• W1574006839 hasConcept C153911025 @default.
• W1574006839 hasConcept C158448853 @default.
• W1574006839 hasConcept C179926584 @default.
• W1574006839 hasConcept C41895202 @default.
• W1574006839 hasConcept C54009773 @default.
• W1574006839 hasConcept C54355233 @default.
• W1574006839 hasConcept C76753757 @default.
• W1574006839 hasConcept C86339819 @default.
• W1574006839 hasConcept C86803240 @default.
• W1574006839 hasConcept C95444343 @default.
• W1574006839 hasConceptScore W1574006839C101762097 @default.
• W1574006839 hasConceptScore W1574006839C104317684 @default.
• W1574006839 hasConceptScore W1574006839C132376346 @default.
• W1574006839 hasConceptScore W1574006839C138885662 @default.

• next