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• W1574113032 startingPage "159" @default.
• W1574113032 abstract "The neurotoxin β-N-oxalylamino-l-alanine (BOAA), found in Lathyrus sativus seeds, is thought to be the causative agent of neurolathyrism. We have investigated the neuroprotective effects of free radical scavengers on BOAA-induced toxicity following focal injection (1 μl) of BOAA and comparing the pathological outcome with the effects of injections of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA), kainate (KA) or N-methyl-d-aspartate (NMDA) into the dorsal hippocampus of male Wistar rats. Cellular damage was assessed histologically. BOAA (50 nmol) induced a highly selective pattern of hippocampal damage identical with that seen with AMPA (1 nmol). BOAA-induced neurotoxicity, but not AMPA, KA (0.5 nmol) or NMDA (25 nmol)-induced neurotoxicity, was prevented in a dose-dependent manner by focal co-injection of four potential free radical scavengers; dimethyl sulphoxide (DMSO) (1750–7000 nmol), dimethylthiourea (DMTU) (8000 nmol), dimethylformamide (DMF) (7000 nmol) and mannitol (1000 nmol). These findings suggest that hippocampal damage induced by BOAA involves an interaction between AMPA receptors and free radicals." @default.
• W1574113032 created "2016-06-24" @default.
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• W1574113032 date "1994-12-01" @default.
• W1574113032 modified "2023-10-16" @default.
• W1574113032 title "Neuroprotective effect of free radical scavengers on (BOAA)-induced neuronal damage in rat hippocampus" @default.
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• W1574113032 doi "https://doi.org/10.1016/0304-3940(94)90787-0" @default.
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