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- W1574132081 abstract "Abstract The endocrine characteristics of polycystic ovarian disease (PCO) remain ill defined as opposed to its histoiogic features. In this study the hypothalamic-pituitary-ovarian interactions were investigated in 26 patients with PCO and compared to those of nine hirsute, anovulatory and 13 healthy, ovulatory control subjects. The following hormones were determined during the early follicular phase: serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) before and after double stimulation with LH-releasing hormone (LHRH) (two doses of 25 μg intravenously at a 120 minute interval, maximal increments after the first injection, i.e., Δ 1 , and second injection, i.e., Δ 2 ), basal testosterone (T), dihydrotestosterone (DHT), astrone (E 1 ), and estradiol (E 2 ). LH Δ 2 was significantly increased in all PCO patients, while LH Δ 1 was elevated in 18 and basal LH in 12 cases. Basal FSH and FSH Δ 1 were normal in all subjects, whereas FSH Δ 2 was higher in two thirds of the women with PCO. A use of peripheral steroids was recorded in the majority Of PCO patients: T in 19, DHT in 16, E 1 in 19, and E 2 in 14 of 23 subjects. Patients with PCO were divided into three subgroups according to their basal LH levels and LH response to stimulation with LHRH. The extent of LH deviation from normal was correlated to the degree of steroidal elevation. The nine hirsute women showed normal gonadotropin patterns despite augmented peripheral androgens. It is concluded that an increase of LH Δ 2 (>12 ng/ml) after LHRH double stimulation combined with positive findings on laparoscopy may be characteristic of PCO in the differential diagnosis of hirsutism, anovulation, and oligomenorrhea." @default.
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- W1574132081 date "1979-08-01" @default.
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- W1574132081 title "Peripheral steroid-gonadotropin interactions and diagnostic significance of double-stimulation tests with luteinizing hormone-releasing hormone in polycystic ovarian disease" @default.
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- W1574132081 doi "https://doi.org/10.1016/0002-9378(79)90952-9" @default.
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