Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574158946> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1574158946 endingPage "1772" @default.
- W1574158946 startingPage "1765" @default.
- W1574158946 abstract "In this report, experiments are described to differentiate between three potential models of class I MHC allorecognition, namely 1) recognition of peptide-free MHC, 2) peptide-MHC-specific recognition, and 3) peptide-MHC-nonspecific recognition. Using a nucleoprotein peptide (NPP) with a sequence derived from influenza virus nucleoprotein with high affinity for Kd class I MHC molecules, it is shown that target cells rapidly become lysable by Kd-NPP self-restricted cytotoxic T (Tc) cells, and retain sufficient Kd-NPP complexes for at least 72 h. Kd-specific alloreactive Tc cells at the clonal and polyclonal level do not show decreased lysis of Kd-bearing targets in the continuous long term (48 h) presence of NPP. Kd-stimulator cells modified with NPP are able to induce potent Kd-NPP-specific self-restricted Tc cells, however Kd-NPP stimulator cells do not generate Kd-NPP specific alloreactive Tc cells from CBA and B10.A (5R) mouse strains as tested by limiting dilution split clone experiments. Human cells infected with the vaccinia virus recombinant coding for the murine Kd class I MHC Ag can be lysed by murine Kd-specific alloreactive Tc cells. In addition the rate of reemergence of alloreactive and self-restricted Tc cell epitopes on virally infected target cells that had their cell-surface class I MHC Ag removed is identical. These results are consistent with model 3 namely that the majority of Tc precursor and effector cells recognize class I MHC Ag without peptide specificity." @default.
- W1574158946 created "2016-06-24" @default.
- W1574158946 creator A5018851262 @default.
- W1574158946 creator A5022725690 @default.
- W1574158946 creator A5031043270 @default.
- W1574158946 creator A5032488465 @default.
- W1574158946 creator A5077365123 @default.
- W1574158946 creator A5086677113 @default.
- W1574158946 date "1991-09-15" @default.
- W1574158946 modified "2023-10-06" @default.
- W1574158946 title "Alloreactive cytotoxic T cells recognize MHC class I antigen without peptide specificity." @default.
- W1574158946 doi "https://doi.org/10.4049/jimmunol.147.6.1765" @default.
- W1574158946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1890303" @default.
- W1574158946 hasPublicationYear "1991" @default.
- W1574158946 type Work @default.
- W1574158946 sameAs 1574158946 @default.
- W1574158946 citedByCount "56" @default.
- W1574158946 countsByYear W15741589462013 @default.
- W1574158946 countsByYear W15741589462014 @default.
- W1574158946 countsByYear W15741589462015 @default.
- W1574158946 countsByYear W15741589462017 @default.
- W1574158946 countsByYear W15741589462020 @default.
- W1574158946 countsByYear W15741589462021 @default.
- W1574158946 crossrefType "journal-article" @default.
- W1574158946 hasAuthorship W1574158946A5018851262 @default.
- W1574158946 hasAuthorship W1574158946A5022725690 @default.
- W1574158946 hasAuthorship W1574158946A5031043270 @default.
- W1574158946 hasAuthorship W1574158946A5032488465 @default.
- W1574158946 hasAuthorship W1574158946A5077365123 @default.
- W1574158946 hasAuthorship W1574158946A5086677113 @default.
- W1574158946 hasBestOaLocation W15741589461 @default.
- W1574158946 hasConcept C147483822 @default.
- W1574158946 hasConcept C153911025 @default.
- W1574158946 hasConcept C154317977 @default.
- W1574158946 hasConcept C170627219 @default.
- W1574158946 hasConcept C195616568 @default.
- W1574158946 hasConcept C197695756 @default.
- W1574158946 hasConcept C200315206 @default.
- W1574158946 hasConcept C202751555 @default.
- W1574158946 hasConcept C203014093 @default.
- W1574158946 hasConcept C207936829 @default.
- W1574158946 hasConcept C2776090121 @default.
- W1574158946 hasConcept C2778814158 @default.
- W1574158946 hasConcept C55493867 @default.
- W1574158946 hasConcept C86803240 @default.
- W1574158946 hasConcept C8891405 @default.
- W1574158946 hasConcept C95444343 @default.
- W1574158946 hasConceptScore W1574158946C147483822 @default.
- W1574158946 hasConceptScore W1574158946C153911025 @default.
- W1574158946 hasConceptScore W1574158946C154317977 @default.
- W1574158946 hasConceptScore W1574158946C170627219 @default.
- W1574158946 hasConceptScore W1574158946C195616568 @default.
- W1574158946 hasConceptScore W1574158946C197695756 @default.
- W1574158946 hasConceptScore W1574158946C200315206 @default.
- W1574158946 hasConceptScore W1574158946C202751555 @default.
- W1574158946 hasConceptScore W1574158946C203014093 @default.
- W1574158946 hasConceptScore W1574158946C207936829 @default.
- W1574158946 hasConceptScore W1574158946C2776090121 @default.
- W1574158946 hasConceptScore W1574158946C2778814158 @default.
- W1574158946 hasConceptScore W1574158946C55493867 @default.
- W1574158946 hasConceptScore W1574158946C86803240 @default.
- W1574158946 hasConceptScore W1574158946C8891405 @default.
- W1574158946 hasConceptScore W1574158946C95444343 @default.
- W1574158946 hasIssue "6" @default.
- W1574158946 hasLocation W15741589461 @default.
- W1574158946 hasLocation W15741589462 @default.
- W1574158946 hasOpenAccess W1574158946 @default.
- W1574158946 hasPrimaryLocation W15741589461 @default.
- W1574158946 hasRelatedWork W1553470951 @default.
- W1574158946 hasRelatedWork W1574158946 @default.
- W1574158946 hasRelatedWork W1823880470 @default.
- W1574158946 hasRelatedWork W1965436963 @default.
- W1574158946 hasRelatedWork W1974826688 @default.
- W1574158946 hasRelatedWork W1992730395 @default.
- W1574158946 hasRelatedWork W2020461604 @default.
- W1574158946 hasRelatedWork W2094582528 @default.
- W1574158946 hasRelatedWork W2159586429 @default.
- W1574158946 hasRelatedWork W310150535 @default.
- W1574158946 hasVolume "147" @default.
- W1574158946 isParatext "false" @default.
- W1574158946 isRetracted "false" @default.
- W1574158946 magId "1574158946" @default.
- W1574158946 workType "article" @default.