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- W1574200424 abstract "This chapter describes the hypothalamo-pituitary axis, its embryology and function. Anterior and posterior pituitary hormones are described as well as their congenital and acquired disorders. Presentation, diagnosis and management of these are covered in detail. Normal pituitary development is carefully orchestrated by a complex pattern of expression of transcription factors and signaling molecules. Pituitary hormone secretion is tightly regulated by a number of hypothalamic releasing and inhibitory hormones. Congenital hypopituitarism is a life-threatening disorder; patients require life-long surveillance. The diagnosis of hypopituitarism requires careful clinical evaluation supported by biochemical testing and neuroimaging; genetic testing may support the diagnosis. Acquired hypopituitarism can be due to traumatic brain injury, tumors such as craniopharyngioma or pituitary germinoma, inflammatory and infective causes, and rarely psychosocial causes." @default.
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- W1574200424 date "2012-02-23" @default.
- W1574200424 modified "2023-09-27" @default.
- W1574200424 title "The Hypothalamo-Pituitary Axis" @default.
- W1574200424 doi "https://doi.org/10.1002/9781119968153.ch3" @default.
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