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- W1574246475 abstract "Chemical genomics is useful in studying essential cellular processes such as endomembrane trafficking pathways. This chapter describes a small molecule – Sortin1 – that connects plant vacuolar trafficking defects and flavonoid metabolism, both of which play important roles in plant growth and development. The compartmentalized endomembrane system ensures proper processing and trafficking of macromolecules to the sites of function. A normally functioning endomembrane trafficking machinery is essential for plant growth and development. Chemical genomics in combination with reverse genetics can identify and integrate different cellular pathways. In the case of Sortin1, chemical genomics connects three cellular processes: protein vacuolar trafficking, flavonoid vacuolar trafficking and metabolism, and vacuole biogenesis. Further identification of target proteins that directly interact with Sortin1 or its active decomposition product will reveal proteins that serve as a linker or hub of three different cellular processes." @default.
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- W1574246475 date "2014-06-27" @default.
- W1574246475 modified "2023-09-24" @default.
- W1574246475 title "Chemical Biology in Plants: Finding New Connections between Pathways Using the Small Molecule Sortin1" @default.
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- W1574246475 doi "https://doi.org/10.1002/9783527687503.ch19" @default.
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