Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574254013> ?p ?o ?g. }
- W1574254013 endingPage "117" @default.
- W1574254013 startingPage "57" @default.
- W1574254013 abstract "At the present time, regulatory T cells (Tregs) are an integral part of immunology but the route from discovery of suppressive lymphocytes in the 1980s to the current established concept of Tregs almost 20 years later has been a rollercoaster ride. Tregs are essential for maintaining self-tolerance as defects in their compartment lead to severe autoimmune diseases. This vitally important function exists alongside the detrimental effects on tumor immunosurveillance and antitumor immunity. Beginning with the identification of CD4(+)CD25(+) Tregs in 1995, the list of Treg subsets, suppressive mechanisms, and knowledge about their various origins is steadily growing. Increase in Tregs within tumors and circulation of cancer patients, observed in early studies, implied their involvement in pathogenesis and disease progression. Several mechanisms, ranging from proliferation to specific trafficking networks, have been identified to account for their systemic and/or local accumulation. Since various immunotherapeutic approaches are being utilized for cancer therapy, various strategies to overcome the antagonistic effects exerted by Tregs are being currently explored. An overview on the biology of Tregs present in cancer patients, their clinical impact, and methods for modulating them is given in this review. Despite the extensive studies on Tregs in cancer many questions still remain unanswered. Even the paradigm that Tregs generally are disadvantageous for the control of malignancies is now under scrutiny. Insight into the specific role of Tregs in different types of neoplasias is the key for targeting them in a way that is beneficial for the clinical outcome." @default.
- W1574254013 created "2016-06-24" @default.
- W1574254013 creator A5011903306 @default.
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- W1574254013 creator A5052339023 @default.
- W1574254013 creator A5074396048 @default.
- W1574254013 creator A5086764600 @default.
- W1574254013 date "2010-01-01" @default.
- W1574254013 modified "2023-10-05" @default.
- W1574254013 title "Regulatory T Cells in Cancer" @default.
- W1574254013 cites W1486722793 @default.
- W1574254013 cites W1503997891 @default.
- W1574254013 cites W1509384822 @default.
- W1574254013 cites W1515471616 @default.
- W1574254013 cites W1522859339 @default.
- W1574254013 cites W1526621387 @default.
- W1574254013 cites W1526933908 @default.
- W1574254013 cites W1530782041 @default.
- W1574254013 cites W1535911598 @default.
- W1574254013 cites W1536480181 @default.
- W1574254013 cites W1539668795 @default.
- W1574254013 cites W1543659825 @default.
- W1574254013 cites W1550301398 @default.
- W1574254013 cites W1555526178 @default.
- W1574254013 cites W1560277370 @default.
- W1574254013 cites W1580678794 @default.
- W1574254013 cites W1587695215 @default.
- W1574254013 cites W1599507531 @default.
- W1574254013 cites W1612801297 @default.
- W1574254013 cites W1619959770 @default.
- W1574254013 cites W1631661663 @default.
- W1574254013 cites W1679167591 @default.
- W1574254013 cites W1700278844 @default.
- W1574254013 cites W1815644294 @default.
- W1574254013 cites W1816367011 @default.
- W1574254013 cites W1833987578 @default.
- W1574254013 cites W1850152419 @default.
- W1574254013 cites W1892261914 @default.
- W1574254013 cites W1895474562 @default.
- W1574254013 cites W1898102248 @default.
- W1574254013 cites W1941651450 @default.
- W1574254013 cites W1962132325 @default.
- W1574254013 cites W1967029979 @default.
- W1574254013 cites W1967215435 @default.
- W1574254013 cites W1967229707 @default.
- W1574254013 cites W1967351618 @default.
- W1574254013 cites W1971347729 @default.
- W1574254013 cites W1971782694 @default.
- W1574254013 cites W1972187865 @default.
- W1574254013 cites W1972746775 @default.
- W1574254013 cites W1973048174 @default.
- W1574254013 cites W1973091654 @default.
- W1574254013 cites W1973131168 @default.
- W1574254013 cites W1977836556 @default.
- W1574254013 cites W1978862810 @default.
- W1574254013 cites W1980069352 @default.
- W1574254013 cites W1980690619 @default.
- W1574254013 cites W1983173932 @default.
- W1574254013 cites W1983306083 @default.
- W1574254013 cites W1984543828 @default.
- W1574254013 cites W1984580912 @default.
- W1574254013 cites W1985126564 @default.
- W1574254013 cites W1986419116 @default.
- W1574254013 cites W1988317772 @default.
- W1574254013 cites W1988474688 @default.
- W1574254013 cites W1988480451 @default.
- W1574254013 cites W1990854674 @default.
- W1574254013 cites W1991344211 @default.
- W1574254013 cites W1992776568 @default.
- W1574254013 cites W1992832092 @default.
- W1574254013 cites W1993211204 @default.
- W1574254013 cites W1993979537 @default.
- W1574254013 cites W1994850185 @default.
- W1574254013 cites W1995570137 @default.
- W1574254013 cites W1995663931 @default.
- W1574254013 cites W1995729484 @default.
- W1574254013 cites W1996123836 @default.
- W1574254013 cites W1996378082 @default.
- W1574254013 cites W1996965524 @default.
- W1574254013 cites W1997139133 @default.
- W1574254013 cites W1998350666 @default.
- W1574254013 cites W1999227421 @default.
- W1574254013 cites W1999569754 @default.
- W1574254013 cites W1999601075 @default.
- W1574254013 cites W2001710477 @default.
- W1574254013 cites W2002726823 @default.
- W1574254013 cites W2003001934 @default.
- W1574254013 cites W2003257616 @default.
- W1574254013 cites W2004014851 @default.
- W1574254013 cites W2004282938 @default.
- W1574254013 cites W2005721095 @default.
- W1574254013 cites W2006631946 @default.
- W1574254013 cites W2010281909 @default.
- W1574254013 cites W2010430022 @default.
- W1574254013 cites W2012177051 @default.
- W1574254013 cites W2013043293 @default.
- W1574254013 cites W2013548919 @default.
- W1574254013 cites W2016875603 @default.