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• W1574271894 startingPage "3229" @default.
• W1574271894 abstract "Traditional pharmacology is defined as the science that deals with drugs and their actions. While small molecule drugs have clear advantages, there are many cases where they have proved to be ineffective, prone to unacceptable side effects, or where due to a particular disease aetiology they cannot possibly be effective. A dominant feature of the small molecule drugs is their single mindedness: they provide either continuous inhibition or continuous activation of the target. Because of that, these drugs tend to engage compensatory mechanisms leading to drug tolerance, drug resistance or, in some cases, sensitization and consequent loss of therapeutic efficacy over time and/or unwanted side effects. Here we discuss new and emerging therapeutic tools and approaches that have potential for treating the majority of disorders for which small molecules are either failing or cannot be developed. These new tools include biologics, such as recombinant hormones and antibodies, as well as approaches involving gene transfer (gene therapy and genome editing) and the introduction of specially designed self-replicating cells. It is clear that no single method is going to be a 'silver bullet', but collectively, these novel approaches hold promise for curing practically every disorder." @default.
• W1574271894 created "2016-06-24" @default.
• W1574271894 creator A5049089914 @default.
• W1574271894 creator A5055148764 @default.
• W1574271894 date "2015-06-10" @default.
• W1574271894 modified "2023-10-13" @default.
• W1574271894 title "Beyond traditional pharmacology: new tools and approaches" @default.
• W1574271894 cites W133175338 @default.
• W1574271894 cites W1489775551 @default.
• W1574271894 cites W1492294380 @default.
• W1574271894 cites W1524361702 @default.
• W1574271894 cites W1529023379 @default.
• W1574271894 cites W1530731118 @default.
• W1574271894 cites W1556070936 @default.
• W1574271894 cites W1588405163 @default.
• W1574271894 cites W1697173196 @default.
• W1574271894 cites W1964493024 @default.
• W1574271894 cites W1965423091 @default.
• W1574271894 cites W1966285532 @default.
• W1574271894 cites W1968409415 @default.
• W1574271894 cites W1971126800 @default.
• W1574271894 cites W1971825415 @default.
• W1574271894 cites W1974710770 @default.
• W1574271894 cites W1977579264 @default.
• W1574271894 cites W1978917197 @default.
• W1574271894 cites W1982690891 @default.
• W1574271894 cites W1983574848 @default.
• W1574271894 cites W1984582197 @default.
• W1574271894 cites W1989321587 @default.
• W1574271894 cites W1990242630 @default.
• W1574271894 cites W1994390268 @default.
• W1574271894 cites W1998177121 @default.
• W1574271894 cites W1998972843 @default.
• W1574271894 cites W2000046950 @default.
• W1574271894 cites W2005089141 @default.
• W1574271894 cites W2006803138 @default.
• W1574271894 cites W2008161734 @default.
• W1574271894 cites W2009664257 @default.
• W1574271894 cites W2017812967 @default.
• W1574271894 cites W2018509153 @default.
• W1574271894 cites W2020635083 @default.
• W1574271894 cites W2022040013 @default.
• W1574271894 cites W2025605951 @default.
• W1574271894 cites W2026493203 @default.
• W1574271894 cites W2028030005 @default.
• W1574271894 cites W2028228274 @default.
• W1574271894 cites W2029335938 @default.
• W1574271894 cites W2029835792 @default.
• W1574271894 cites W2030222651 @default.
• W1574271894 cites W2030621748 @default.
• W1574271894 cites W2030783842 @default.
• W1574271894 cites W2033688302 @default.
• W1574271894 cites W2034124491 @default.
• W1574271894 cites W2035110063 @default.
• W1574271894 cites W2038866304 @default.
• W1574271894 cites W2039705224 @default.
• W1574271894 cites W2041654178 @default.
• W1574271894 cites W2041797639 @default.
• W1574271894 cites W2043409056 @default.
• W1574271894 cites W2045197562 @default.
• W1574271894 cites W2045650410 @default.
• W1574271894 cites W2045794140 @default.
• W1574271894 cites W2049741610 @default.
• W1574271894 cites W2050307742 @default.
• W1574271894 cites W2050972073 @default.
• W1574271894 cites W2055583081 @default.
• W1574271894 cites W2056502442 @default.
• W1574271894 cites W2057261198 @default.
• W1574271894 cites W2057757999 @default.
• W1574271894 cites W2058095641 @default.
• W1574271894 cites W2059228484 @default.
• W1574271894 cites W2060710536 @default.
• W1574271894 cites W2061184966 @default.
• W1574271894 cites W2061534502 @default.
• W1574271894 cites W2064403224 @default.
• W1574271894 cites W2066594212 @default.
• W1574271894 cites W2066745538 @default.
• W1574271894 cites W2068351024 @default.
• W1574271894 cites W2070708023 @default.
• W1574271894 cites W2072102778 @default.
• W1574271894 cites W2072572338 @default.
• W1574271894 cites W2073377349 @default.
• W1574271894 cites W2074370114 @default.
• W1574271894 cites W2075230442 @default.
• W1574271894 cites W2075668934 @default.
• W1574271894 cites W2075906033 @default.
• W1574271894 cites W2077410783 @default.
• W1574271894 cites W2079520721 @default.
• W1574271894 cites W2080885049 @default.
• W1574271894 cites W2090858556 @default.
• W1574271894 cites W2093664801 @default.
• W1574271894 cites W2096791413 @default.
• W1574271894 cites W2097226043 @default.
• W1574271894 cites W2099106733 @default.
• W1574271894 cites W2102718460 @default.
• W1574271894 cites W2104978512 @default.
• W1574271894 cites W2106594935 @default.
• W1574271894 cites W2107086950 @default.

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