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- W1574286681 abstract "Top of pageAbstractBackground: Synthetic vascular graft performance is inferior to autologous vein grafts. This study investigated if 1) local administration of plasmids encoding for human vascular endothelial growth factor (pNGVL3-VEGF165) or h-VEGF165/FGF-2 combination or 2) graft design affect synthetic graft endothelialisation and patency.Methods and Results: Rat abdominal aorta (n=132) was replaced with 60 microns ePTFE graft and pNGVL3-VEGF165, pNGVL3-VEGF165/FGF-2 combination or control plasmid were administered. In rabbits (n=90), polyester, 60 microns ePTFE, hybrid ePTFE, or 30 microns ePTFE grafts and pNGVL3-VEGF165 or control plasmids were used. Rats were sacrificed after 1, 2, 4 or 77 weeks and rabbits after 2, 4, 12 or 43 weeks. In dogs, 60 microns ePTFE (n=10) or polyester grafts (n=10) were inoperated to carotid and hybrid ePTFE grafts (n=15) to femoral position, followed by injection of pNGVL3-VEGF165 or control plasmid. Dogs were sacrificed at 6 weeks. Endothelialisation was determined in the midgraft area with scanning electron microscopy (SEM). pNGVL3-VEGF165 enhanced endothelialisation at every time point in rats, whereas plasmids encoding h-VEGF165/FGF-2 combination had worst outcome at 1 week (NS), 2 weeks (p=0.01) and at 4 weeks (p=0.02). In rabbits, polyester grafts had a trend for faster endothelialisation (p=0.08) and pNGVL3-VEGF165 enhanced endothelialisation at 2 weeks (p=0.06) but the effect reversed at 4 weeks (p=0.03). pNGVL3-VEGF165 improved hybrid ePTFE patency in dogs (p=0,103).Conclusions: Improved early endothelialisation and patency with local administration of pNGVL3-VEGF165 reveal a new concept for enhancement of synthetic vascular graft performance with gene therapy.Was founder of the Company but has no indirect, direct or other businesses with buyer of the IP assets Fit Biotech Oyj." @default.
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- W1574286681 date "2005-05-01" @default.
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- W1574286681 title "630. In Vivo h- VEGF165 Gene Transfer Improves Early Endothelialisation and Patency in Synthetic Vascular Grafts" @default.
- W1574286681 doi "https://doi.org/10.1016/j.ymthe.2005.07.170" @default.
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