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- W1574316151 abstract "The expression of the dihydropyridine (DHP) and ryanodine receptors in skeletal muscle was investigated during development of rat myotubes in culture as well as during embryonic and postnatal development in the rat. Through the use of specific gene probes, antibodies and radioligand binding ([3H]PN 200-110 (DHP) and [3H]ryanodine), we identified a significant difference between the time course of appearance of the DHP receptor and the ryanodine receptor during muscle development. Although the number of DHP receptors dramatically increased at early stages of development (up to day 7 in tissue culture and day 20 postnatal), increase in the ryanodine receptor density occurred comparatively later at day 10 in culture and day 30 postnatal. This process was associated with parallel changes in the expression of the mRNA encoding the alpha 1, alpha 2, and beta subunits of the DHP receptor and the skeletal muscle ryanodine receptor. The genes encoding the DHP receptor subunits were activated in a temporally distinct transcript appeared and plateaued first, at the onset of myoblast fusion and day 16 embryonic. This was followed closely by an increase in expression of the mRNAs for alpha 1 and alpha 2 subunits which coincided with the sharp rise in the DHP receptor density. Ryanodine receptor gene expression was induced well after the DHP receptor gene expression had plateaued. The temporal appearance of the polypeptides comprising the DHP receptor subunits and the ryanodine receptor paralleled the induction of the genes encoding these receptors. These results imply that gene expression is a major mechanism that contributes to the regulation of DHP and ryanodine receptor numbers during muscle development. The temporal differences in the induction of the genes encoding the DHP receptor subunits and the ryanodine receptor suggests that these genes are under the control of distinct endogenous factors. These differences in expression of the DHP receptor and the ryanodine receptor may contribute to the different mechanisms of excitation-contraction coupling in immature versus adult skeletal muscle." @default.
- W1574316151 created "2016-06-24" @default.
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- W1574316151 creator A5061861053 @default.
- W1574316151 date "1994-08-01" @default.
- W1574316151 modified "2023-10-17" @default.
- W1574316151 title "Temporal differences in the induction of dihydropyridine receptor subunits and ryanodine receptors during skeletal muscle development." @default.
- W1574316151 cites W12635643 @default.
- W1574316151 cites W1508736526 @default.
- W1574316151 cites W1525891657 @default.
- W1574316151 cites W1526096964 @default.
- W1574316151 cites W1533465487 @default.
- W1574316151 cites W1570967829 @default.
- W1574316151 cites W1585798997 @default.
- W1574316151 cites W1601185542 @default.
- W1574316151 cites W1740533879 @default.
- W1574316151 cites W1777610481 @default.
- W1574316151 cites W1836747283 @default.
- W1574316151 cites W1901485533 @default.
- W1574316151 cites W1952906612 @default.
- W1574316151 cites W1973150566 @default.
- W1574316151 cites W1974543599 @default.
- W1574316151 cites W1976257073 @default.
- W1574316151 cites W1980444911 @default.
- W1574316151 cites W1983361084 @default.
- W1574316151 cites W1989714306 @default.
- W1574316151 cites W1990205754 @default.
- W1574316151 cites W1990474329 @default.
- W1574316151 cites W1993117363 @default.
- W1574316151 cites W1997495355 @default.
- W1574316151 cites W1998318605 @default.
- W1574316151 cites W1999503127 @default.
- W1574316151 cites W2002917361 @default.
- W1574316151 cites W2003758393 @default.
- W1574316151 cites W2006192148 @default.
- W1574316151 cites W2007014490 @default.
- W1574316151 cites W2011533557 @default.
- W1574316151 cites W2012093804 @default.
- W1574316151 cites W2013070374 @default.
- W1574316151 cites W2013682104 @default.
- W1574316151 cites W2018766046 @default.
- W1574316151 cites W2018771017 @default.
- W1574316151 cites W2022186297 @default.
- W1574316151 cites W2024929666 @default.
- W1574316151 cites W2025086061 @default.
- W1574316151 cites W2026686753 @default.
- W1574316151 cites W2028868439 @default.
- W1574316151 cites W2031423487 @default.
- W1574316151 cites W2036396000 @default.
- W1574316151 cites W2036937904 @default.
- W1574316151 cites W2037048489 @default.
- W1574316151 cites W2039547987 @default.
- W1574316151 cites W2054151386 @default.
- W1574316151 cites W2056622362 @default.
- W1574316151 cites W2065267195 @default.
- W1574316151 cites W2068833551 @default.
- W1574316151 cites W2071559339 @default.
- W1574316151 cites W2076371532 @default.
- W1574316151 cites W2077749564 @default.
- W1574316151 cites W2078718449 @default.
- W1574316151 cites W2078960179 @default.
- W1574316151 cites W2082299946 @default.
- W1574316151 cites W2083310303 @default.
- W1574316151 cites W2086157488 @default.
- W1574316151 cites W2087651417 @default.
- W1574316151 cites W2090428859 @default.
- W1574316151 cites W2100906077 @default.
- W1574316151 cites W2101108802 @default.
- W1574316151 cites W2102598251 @default.
- W1574316151 cites W2103735500 @default.
- W1574316151 cites W2115994363 @default.
- W1574316151 cites W2116237432 @default.
- W1574316151 cites W2131431331 @default.
- W1574316151 cites W2131601923 @default.
- W1574316151 cites W2138027883 @default.
- W1574316151 cites W2139046781 @default.
- W1574316151 cites W2161957047 @default.
- W1574316151 cites W2164615251 @default.
- W1574316151 cites W2169397244 @default.
- W1574316151 cites W2226437153 @default.
- W1574316151 cites W2275889027 @default.
- W1574316151 cites W2329380619 @default.
- W1574316151 cites W2405695988 @default.
- W1574316151 cites W4235579029 @default.
- W1574316151 cites W4376453111 @default.
- W1574316151 doi "https://doi.org/10.1016/s0021-9258(17)31871-9" @default.
- W1574316151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8063821" @default.
- W1574316151 hasPublicationYear "1994" @default.
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