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• W1574328632 abstract "Abstract Background and Aim Although differences in genetic susceptibility and the clinical features of C rohn's disease ( CD ) have been reported between A sian and C aucasian patients, the disease course and predictors of CD in A sians remains poorly defined. The study therefore aimed to investigate factors predictive of the clinical outcomes of patients with CD in a K orean population. Methods This retrospective multicenter cohort study included 728 K orean CD patients from 13 university hospitals. The first CD ‐related surgery or need for immunosuppressive or biological agents were regarded as the clinical outcomes of interest. Results A total of 126 (17.3%) CD patients underwent CD ‐related surgery, while 473 (65.0%) and 196 (26.9%) were prescribed thiopurine drugs and infliximab, respectively. Multivariate C ox regression analysis identified current (hazard ratio [ HR ] = 1.86; P = 0.018) and former smoking habits ( HR = 1.78; P = 0.049), stricturing ( HR = 2.24; P < 0.001), and penetrating disease behavior at diagnosis ( HR = 3.07; P < 0.001) as independent predictors associated with the first CD ‐related surgery. With respect to immunosuppressive and biological agents, younger age (< 40 years) ( HR = 2.17; P < 0.001 and HR = 2.10; P = 0.006, respectively), ileal involvement ( HR = 1.36; P = 0.035 and HR = 2.17; P = 0.006, respectively), and perianal disease ( HR = 1.42; P = 0.001 and HR = 1.38; P = 0.038, respectively) at diagnosis were significant predictors for the need of these medications. Conclusions In K orean patients with CD , stricturing, penetrating disease behavior, and smoking habits at the time of diagnosis are independent predictors for CD ‐related surgery. It was also identified that younger age (< 40 years), ileal involvement, and perianal disease at diagnosis are predictive of a need for immunosuppressive or biological agents." @default.
• W1574328632 created "2016-06-24" @default.
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• W1574328632 date "2013-12-19" @default.
• W1574328632 modified "2023-10-03" @default.
• W1574328632 title "Clinical features and predictors of clinical outcomes in Korean patients with Crohn's disease: A Korean Association for the Study of Intestinal Diseases multicenter study" @default.
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• W1574328632 doi "https://doi.org/10.1111/jgh.12369" @default.
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