Matches in SemOpenAlex for { <https://semopenalex.org/work/W157436130> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W157436130 endingPage "9" @default.
- W157436130 startingPage "625" @default.
- W157436130 abstract "Lathyrism, one of the oldest neurotoxic diseases known to Man, results from excessive consumption of the chickling pea, Lathyrus sativus, and certain related species. Once prevalent throughout Europe, N. Africa, Middle East and parts of the Far East, the disease is presently restricted to India, Bangladesh and Ethiopia. Lathyrism is a form of irreversible, non-progressive spastic paraparesis associated with poorly understood degenerative changes in spinal cord. Domestic animals, notably the horse, also develop hindlimb paralysis after prolonged feeding on lathyrus fodder. Experimental animal models of lathyrism have been reported but none has been satisfactorily investigated, and concurrence between these experimental diseases and the human condition is unproven. The culpable agent in lathyrus species that precipitates paralysis also is unknown. Current attention is focused on the glutamate analog, beta-(N)-oxalyl-amino-L-alanine acid (BOAA). While this compound is present in those lathyrus species that induce spastic paraparesis and, in large doses, reportedly causes neuropathological changes similar to glutamate neurotoxicity, there is little to compare these neuropathological changes with those found in human lathyrism. Chronic primate feeding studies utilizing BOAA need to be carried out to determine whether this agent is responsible for human lathyrism. Some species of lathyrus, notably Lathyrus odoratus, are unable to induce human lathyrism but contain a compound, beta-aminopropionitrile (BAPN), that induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. However, related compounds, dimethylaminopropionitrile (DMAPN) and beta, beta'-iminodipropionitrile (IDPN), are chronic neurotoxins in humans and animals, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W157436130 created "2016-06-24" @default.
- W157436130 creator A5029339920 @default.
- W157436130 creator A5076619105 @default.
- W157436130 date "1983-11-01" @default.
- W157436130 modified "2023-09-29" @default.
- W157436130 title "Lathyrism: a neurotoxic disease." @default.
- W157436130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6422318" @default.
- W157436130 hasPublicationYear "1983" @default.
- W157436130 type Work @default.
- W157436130 sameAs 157436130 @default.
- W157436130 citedByCount "28" @default.
- W157436130 countsByYear W1574361302012 @default.
- W157436130 countsByYear W1574361302014 @default.
- W157436130 countsByYear W1574361302015 @default.
- W157436130 countsByYear W1574361302017 @default.
- W157436130 countsByYear W1574361302019 @default.
- W157436130 countsByYear W1574361302020 @default.
- W157436130 countsByYear W1574361302022 @default.
- W157436130 countsByYear W1574361302023 @default.
- W157436130 crossrefType "journal-article" @default.
- W157436130 hasAuthorship W157436130A5029339920 @default.
- W157436130 hasAuthorship W157436130A5076619105 @default.
- W157436130 hasConcept C118552586 @default.
- W157436130 hasConcept C126322002 @default.
- W157436130 hasConcept C2776915367 @default.
- W157436130 hasConcept C2779207274 @default.
- W157436130 hasConcept C2779421357 @default.
- W157436130 hasConcept C2779491297 @default.
- W157436130 hasConcept C2779636300 @default.
- W157436130 hasConcept C29730261 @default.
- W157436130 hasConcept C59822182 @default.
- W157436130 hasConcept C71924100 @default.
- W157436130 hasConcept C86803240 @default.
- W157436130 hasConceptScore W157436130C118552586 @default.
- W157436130 hasConceptScore W157436130C126322002 @default.
- W157436130 hasConceptScore W157436130C2776915367 @default.
- W157436130 hasConceptScore W157436130C2779207274 @default.
- W157436130 hasConceptScore W157436130C2779421357 @default.
- W157436130 hasConceptScore W157436130C2779491297 @default.
- W157436130 hasConceptScore W157436130C2779636300 @default.
- W157436130 hasConceptScore W157436130C29730261 @default.
- W157436130 hasConceptScore W157436130C59822182 @default.
- W157436130 hasConceptScore W157436130C71924100 @default.
- W157436130 hasConceptScore W157436130C86803240 @default.
- W157436130 hasIssue "6" @default.
- W157436130 hasLocation W1574361301 @default.
- W157436130 hasOpenAccess W157436130 @default.
- W157436130 hasPrimaryLocation W1574361301 @default.
- W157436130 hasRelatedWork W1511632494 @default.
- W157436130 hasRelatedWork W157436130 @default.
- W157436130 hasRelatedWork W1838938044 @default.
- W157436130 hasRelatedWork W1991103574 @default.
- W157436130 hasRelatedWork W2041342590 @default.
- W157436130 hasRelatedWork W2049143547 @default.
- W157436130 hasRelatedWork W2083414763 @default.
- W157436130 hasRelatedWork W2259928693 @default.
- W157436130 hasRelatedWork W244781688 @default.
- W157436130 hasRelatedWork W2883628509 @default.
- W157436130 hasVolume "5" @default.
- W157436130 isParatext "false" @default.
- W157436130 isRetracted "false" @default.
- W157436130 magId "157436130" @default.
- W157436130 workType "article" @default.