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- W1574364038 abstract "Abstract Cephalothin, penicillin G and probenecid inhibited GSH organic nitrate ester reductase (ONER) and several other enzymatic activities of GSH- S -transferases (EC 2.5.1.18) from rat and guinea pig liver. Erythrityl tetranitrate, a substrate for ONER, inhibited the aryl and alkyl transferase activities of two guinea pig liver GSH- S -transferases. These findings support the concept that ONER is one of the several activities possessed by the GSH- S -transferases. In an examination of possible in vivo action, parenteral administration of these inhibitors 2–30 min prior to i.v. administration of [ 14 C]glyceryl trinitrate resulted in a 50–100 per cent increase in the half-time of the metabolism phase of [ 14 C]glyceryl trinitrate clearance from the blood and postponed the appearance of metabolites. This presumably occurs through the in vivo inhibition of GSH-ONER activity of the GSH- S -transferases and suggests a possible means of prolonging the pharmacologie action of nitrate esters." @default.
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- W1574364038 date "1980-06-01" @default.
- W1574364038 modified "2023-10-16" @default.
- W1574364038 title "Extension of the blood half-life of glyceryl trinitrate" @default.
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- W1574364038 doi "https://doi.org/10.1016/0006-2952(80)90143-4" @default.
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