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- W1574393971 abstract "Publisher Summary This chapter describes the way to use biochemical methods for identifying a minimal RNA sequence that mimics the aminoglycoside binding site on the ribosome. It also discusses the way to apply nuclear magnetic resonance (NMR) spectroscopy for identifying the site of interaction of the antibiotic on the oligonucleotide to subsequently determine the 3-D structure of the antibiotic–RNA complex. Chemical modification reactions are performed on the oligonucleotide in a buffer similar to that used for characterizing the interaction of the ribosome with aminoglycoside antibiotics. Several factors make the aminoglycoside–ribosomal RNA (rRNA) complex amenable to NMR study. First, the interaction of aminoglycosides with the ribosome has been previously characterized biochemically. Second, the site of interaction of the drug is localized to a small region of the 16S rRNA. Third, this region of rRNA does not appear to interact with ribosomal proteins. These factors suggest that the local structure of this region of rRNA could be maintained in an oligonucleotide in the absence of any of the ribosomal proteins." @default.
- W1574393971 created "2016-06-24" @default.
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- W1574393971 date "2000-01-01" @default.
- W1574393971 modified "2023-09-25" @default.
- W1574393971 title "[16] Biochemical and nuclear magnetic resonance studies of aminoglycoside-RNA complexes" @default.
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- W1574393971 doi "https://doi.org/10.1016/s0076-6879(00)17018-1" @default.
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