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- W1574395250 endingPage "4079" @default.
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- W1574395250 abstract "Abstract Caspases, a family of cysteine proteases, are critical mediators of apoptosis. To address the importance of caspases in thymocyte development, we have generated transgenic mice that express the baculovirus protein p35, a viral caspase inhibitor, specifically in the thymus. p35 expression inhibited Fas (CD95)-, CD3-, or peptide-induced caspase activity in vitro and conferred resistance to Fas-induced apoptosis. However, p35 did not block specific peptide-induced negative selection in OT1 and HY TCR transgenic mouse models. Even the potent pharmacological caspase inhibitor zVAD-FMK (benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl-ketone) could not prevent peptide-induced deletion of OT1 thymocytes, although it improved basal thymocyte survival in vitro. Moreover, the developmental block observed in rag1−/− thymocytes, which lack pre-TCR signaling, was also not rescued by p35 expression. These results indicate that caspase-independent signal transduction pathways can mediate thymocyte death during normal T cell development." @default.
- W1574395250 created "2016-06-24" @default.
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- W1574395250 date "2000-04-15" @default.
- W1574395250 modified "2023-09-25" @default.
- W1574395250 title "Caspase Enzyme Activity Is Not Essential for Apoptosis During Thymocyte Development" @default.
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- W1574395250 doi "https://doi.org/10.4049/jimmunol.164.8.4071" @default.
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