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- W1574397195 abstract "Monomeric Rho GTPases regulate cellular dynamics through remodeling of the cytoskeleton, modulation of immediate signaling pathways, and longer-term regulation of gene transcription. One family of guanine nucleotide exchange factors for Rho proteins (RhoGEFs) provides a direct pathway for regulation of RhoA by cell surface receptors coupled to heterotrimeric G proteins. Some of these RhoGEFs also contain RGS domains that can attenuate signaling by the G(12) and G(13) proteins. The regulation provided by these RhoGEFs is defined by their selective regulation by specific G proteins, phosphorylation by kinases, and potential localization with signaling partners. Evidence of their physiological importance is derived from gene knockouts in Drosophila and mice. Current understanding of the basic regulatory mechanisms of these RhoGEFs is discussed. An overview of identified interactions with other signaling proteins suggests the growing spectrum of their involvement in numerous signaling pathways." @default.
- W1574397195 created "2016-06-24" @default.
- W1574397195 creator A5001377302 @default.
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- W1574397195 creator A5039319154 @default.
- W1574397195 creator A5083879051 @default.
- W1574397195 date "2007-01-01" @default.
- W1574397195 modified "2023-09-27" @default.
- W1574397195 title "Regulation of Rho Guanine Nucleotide Exchange Factors by G Proteins" @default.
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